163 Longitudinal tau PET and cognition SUPPLEMENTARY MATERIAL Supplementary Figure 1. Associations between annual change in R1 with cognitive test scores (over time). Model coefficients with 95% confidence intervals from linear mixed models with annual change in R1 as determinant, longitudinal cognitive test score (scaled) as outcome, adjusted for age-at-PET, sex, education, and baseline R1. Cross-sectional results represent the coefficient for “annual change in R1” and longitudinal results represent the coefficient for “annual change in R1 x time”. Red = PFDR<0.05. Blue = P<0.05. Grey = P≥0.05. 6
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