155 Longitudinal tau PET and cognition Figure 4. Associations between annual change (AC) in tau PET BPND with cognitive test scores at baseline and over time while adjusting for R1. Model coefficients with 95% confidence intervals from linear mixed models with annual change in tau PET BPND (per ROI) and annual change in R1 as determinant, longitudinal cognitive test score (scaled) as outcome, adjusted for age-at-PET, sex, education, baseline tau PET BPND (per ROI) and baseline R1. Cross-sectional results represent the coefficient for “annual change in tau PET BPND (per ROI)” and longitudinal results represent the coefficient for “annual change in tau PET BPND (per ROI) x time”. Red = PFDR<0.05. Blue = P<0.05. Grey = P≥0.05. 6
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