147 Longitudinal tau PET and cognition BPND in Braak I was associated with lower concurrent MMSE only, yet associations with rate of decline were manifold, as there were associations with a steeper rate of decline on all tests, except for tau PET BPND in Braak V/VI and rate of decline on the TMT-B (Figure 1). Beta’s ranged from -0.11 (SE 0.05; Braak I~TMT-B) to -0.58 (SE 0.16; Braak III/IVRAVLT) (Figure 1). Table 1. Sample characteristics Cognitively unimpaired Cognitively impaired Sample size, n 54 75 Age at BL PET, y 66 ± 7 65 ± 8 Sex, n female (%) 29 (54%) 39 (52%) Education, Verhage 6 [5-6] 2 unknown 6 [5-6] APOE ε4 status, n carrier (%) 21 (39%) 2 unknown 54 (72%) 4 unknown a Amyloid-β status, n positive (%) 20 (37%) 75 (100%)a MMSE at BL PET 29 ± 1 22 ± 4a MMSE annual change 0.1 ± 0.0 * -0.7 ± 0.1*** RAVLT immediate recall (sum) at BL PET 46 ± 9 24 ± 9 a RAVLT immediate recall (sum) annual change 0.2 ± 0.2 -1.4 ± 0.3*** TMT-B at BL PET, sec 76 ± 35 192 ± 101 a TMT-B annual change 0.8 ± 0.6 4.8 ± 3.5 Follow-up time neuropsychological tests, y 6.2 ± 2.4 3.1 ± 1.5 Sample size FU PET, n 49 37 Time BL-FU PET, y 1.99 ± 0.45 2.27 ± 0.62 Braak I BPND at baseline -0.03 ± 0.17 0.34 ± 0.22 a Braak I BPND annual change 0.03 ± 0.09 0.02 ± 0.04 Braak III/IV BPND at baseline 0.05 ± 0.09 0.33 ± 0.20 a Braak III/IV BPND annual change 0.01 ± 0.02 0.03 ± 0.04 Braak V/VI BPND at baseline 0.05 ± 0.07 0.38 ± 0.30 a Braak V/VI BPND annual change 0.01 ± 0.02 0.03 ± 0.06 Global R1 at baseline 0.91 ± 0.04 0.87 ± 0.05 a Global R1 annual change 0.00 ± 0.01 -0.01 ± 0.01 Age and neuropsychological test scores at baseline (BL) PET and (annual change in) BPND or R1 are shown as mean ± standard deviation. Annual changes in test scores are shown as the estimate (from a linear regression model test ~ time (in years)) ± standard error. Education is shown as median [interquartile range]. Education reflects the Dutch Verhage score. Education was missing for n=2 CU. APOE ε4 status was missing for n=2 CU and n=4 CI. *annual change in test score p<0.05. *** annual change in test score p<0.001. a difference between cognitively unimpaired and –impaired p<0.001. 6
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