130 Chapter 5 SUPPLEMENTARY MATERIAL Supplementary Table 1. Demographics, [18F]flortaucipir BP ND and R1 of n=72 (cognition) sample. Depicted are mean (SD), unless specified otherwise, for earlyonset AD (EOAD) and late-onset AD (LOAD) groups. Median [range] is depicted for education. APOE ε4 status was unknown for four LOAD subjects. Independent sample T-test or χ2 test was used for demographic variables. Differences in [18F] flortaucipir BPND or R1 were assessed using ANOVA, adjusted for sex. *The Dutch Verhage scale for education includes 7 ascending categories, ranging from one (representing less than six years of primary education) to 7 (representing a university degree). EOAD LOAD p-values Sample size (n) 30 42 Age (years) 59 (5) 71 (5) <0.001 Females n (%) 14 (47) 19 (45) ~1 Education (Verhage scale*) 6 [3-7] 5 [3-7] 0.637 MMSE 23 (3) 23 (4) 0.708 APOE4 ε4 carriership, n/ntotal 21/30 33/38 0.757 [18F]flortaucipir BP ND Medial temporal 0.24 (0.14) 0.25 (0.18) 0.842 Lateral temporal 0.55 (0.31) 0.42 (0.30) 0.081 Parietal 0.84 (0.51) 0.33 (0.29) <0.001 Occipital 0.64 (0.54) 0.29 (0.23) <0.001 Frontal 0.38 (0.30) 0.16 (0.23) <0.001 [18F]flortaucipir R 1 Medial temporal 0.69 (0.04) 0.66 (0.05) 0.004 Lateral temporal 0.86 (0.06) 0.84 (0.07) 0.155 Parietal 0.86 (0.09) 0.87 (0.08) 0.794 Occipital 0.97 (0.09) 0.97 (0.08) 0.891 Frontal 0.89 (0.06) 0.87 (0.06) 0.209
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