129 Tau PET and cognition in early- and late onset AD 55. Ossenkoppele, R., et al., Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging. JAMA neurology, 2021. 56. Gerritsen, A.A., et al., Prevalence of comorbidity in patients with young-onset Alzheimer disease compared with late-onset: a comparative cohort study. Journal of the American Medical Directors Association, 2016. 17(4): p. 318-323. 57. Ortner, M., et al., Small vessel disease, but neither amyloid load nor metabolic deficit, is dependent on age at onset in Alzheimer’s disease. Biological psychiatry, 2015. 77(8): p. 704-710. 58. Igelström, K.M. and M.S. Graziano, The inferior parietal lobule and temporoparietal junction: a network perspective. Neuropsychologia, 2017. 105: p. 70-83. 59. Engels, M., et al., Alzheimer’s disease: the state of the art in resting-state magnetoencephalography. Clinical Neurophysiology, 2017. 128(8): p. 1426-1437. 60. Brier, M.R., et al., Loss of intranetwork and internetwork resting state functional connections with Alzheimer’s disease progression. Journal of Neuroscience, 2012. 32(26): p. 8890-8899. 61. Seeley, W.W., et al., Neurodegenerative diseases target large-scale human brain networks. Neuron, 2009. 62(1): p. 42-52. 62. Rabinovici, G.D., et al., Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden. Brain, 2010. 133(2): p. 512-528. 63. Chen, J.J., H.D. Rosas, and D.H. Salat, Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage, 2011. 55(2): p. 468-478. 64. Cho, H., et al., Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer’s disease. Neurobiology of aging, 2017. 53: p. 103-111. 65. Vogel, J.W., et al., Four distinct trajectories of tau deposition identified in Alzheimer’s disease. Nature Medicine, 2021: p. 1-11. 66. Smith, R., et al., Posterior accumulation of tau and concordant hypometabolism in an early-onset Alzheimer’s disease patient with presenilin-1 mutation. Journal of Alzheimer’s Disease, 2016. 51(2): p. 339-343. 67. Gordon, B.A., et al., Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers. Brain, 2019. 142(4): p. 1063-1076. 68. van der Flier, W.M., et al., Early-onset versus late-onset Alzheimer’s disease: the case of the missing APOE ε4 allele. The Lancet Neurology, 2011. 10(3): p. 280-288. 69. Ten Kate, M., et al., Impact of APOE-ε4 and family history of dementia on gray matter atrophy in cognitively healthy middle-aged adults. Neurobiology of aging, 2016. 38: p. 14-20. 70. Mattsson, N., et al., Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study. Alzheimer’s research & therapy, 2018. 10(1): p. 1-12. 5
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