119 Tau PET and cognition in early- and late onset AD parietal BPND with TMT-B were stronger than in late-onset AD (all pinteraction<0.10; Figure 4). In late-onset AD, associations between medial temporal BPND and Digit Span backward and Letter fluency test (D-A-T) were stronger than in early-onset AD (Figure 4). Results from partial volume corrected data were essentially comparable (Supplementary Figure 7). Figure 3. [18F]flortaucipir R 1 for early- and late-onset AD. a) Boxplot of [ 18F]flortaucipir R1 values for each region-of-interest (ROI). b-f) Scatterplots for [ 18F]flortaucipir R1 by age for each ROI. g) Results from voxel-wise contrast for [ 18F]flortaucipir R 1 between early-onset AD (EOAD) and late-onset AD (LOAD). Indicated by the black lines on the color scale are thresholds for p<0.001, uncorrected (t = 3.20) and for p<0.05, FWE-corrected (t = 5.24). *p<0.05. 5
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