118 Chapter 5 Figure 2. [18F]flortaucipir BP ND for early- and late-onset AD. a) Boxplot of [ 18F]flortaucipir BPND values for each region-of-interest (ROI). Differences were assessed using ANOVA, adjusted for sex. b-f) Scatterplots for [18F]flortaucipir BP ND by age for each ROI. g) Results from voxel-wise contrast for [18F]flortaucipir BP ND between early-onset AD (EOAD) and late-onset AD (LOAD). Indicated by the black lines on the color scale are thresholds for p<0.001, uncorrected (t = 3.20) and for p<0.05, FWE-corrected (t = 5.24). *p<0.05, **p<0.01, ***p<0.001, †p FDR<0.05. Early- and late-onset AD di erences in the association between BPND and cognition Linear regression analyses showed that, in general, higher [18F]flortaucipir BP ND was strongly associated with worse scores on a variety of cognitive tests (Figure 4a). Age-at-onset moderated these associations such that in early-onset AD, associations between lateral temporal, parietal and occipital BPND with TMT-A, and
RkJQdWJsaXNoZXIy MjY0ODMw