117 Tau PET and cognition in early- and late onset AD Figure 1. Average [18F]flortaucipir BP ND images for early- and late-onset AD, PCA and bvAD. Average images of all early-onset Alzheimer’s disease (EOAD), late-onset AD (LOAD), posterior cortical atrophy (PCA) patients and behavioral variant AD (bvAD) patients on a scale ranging from BPND 0 to 1.5. *Excluding atypical variants, posterior cortical atrophy (PCA) patients and behavioral variant AD (bvAD) patients Early- and late-onset AD di erences in R1 By contrast, [18F]flortaucipir R 1 was lower in late-onset AD compared to early-onset AD in the medial temporal lobe (R1 0.66±0.05 vs 0.69±0.05, p<0.05), but not in any of the neocortical regions (p>0.05) (Figure 3). Voxel-wise analyses showed lower R1 in the (medial) temporal lobe (surviving FWE-correction), and subtly lower R1 in the medial frontal cortex in late-onset compared to early-onset AD (Figure 3g). In contrast, parieto-occipital regions showed lower R1 in early-onset AD compared to late-onset AD, but this did not survive FWE-correction. Results remained essentially unchanged when atypical cases were excluded from the analysis (Supplementary Figure 5). Results from partial volume corrected data yielded highly similar results, although R1 values were slightly higher (Supplementary Figure 6). 5
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