116 Chapter 5 Early- and late-onset AD di erences in BPND Early-onset AD patients showed higher [18F]flortaucipir BP ND in lateral temporal (BPND 0.56±0.30 vs 0.42±0.30, p=0.045), parietal (BPND 0.84±0.50 vs 0.33±0.29, p<0.001), occipital (BPND 0.65±0.52 vs 0.29±0.23, p<0.001) and frontal cortex (BPND 0.40±0.30 vs 0.16±0.23, p<0.001) compared to late-onset AD (Figure 2).There were no differences in medial temporal BPND between early-onset AD (0.24±0.14) and late-onset AD (0.25±0.18, p=0.895). Voxel-wise analyses confirmed higher BPND in widespread neocortical regions in early- vs late-onset AD (Figure 2g). Effects were most pronounced in the precuneus and posterior cingulate, and fronto-temporal cortex, as supported by the FWE-corrected results. There were no regions in which late-onset AD showed higher BPND compared to early-onset AD (Figure 2g). Results remained essentially unchanged when PCA and bvAD patients were excluded from the analysis (Supplementary Figure 3). Furthermore, results from partial volume corrected data yielded highly similar results, although BPND values were slightly higher (Supplementary Figure 4).
RkJQdWJsaXNoZXIy MjY0ODMw