105 Tau PET and cognition Supplementary Table 4. Continued. Memory (n=71) Executive functioning (n=64) Language (n=59) Attention (n=64) Model 2 Medial temporal BPND -0.43‡§ [-0.66 − -0.20] -0.12 [-0.36 − 0.13] -0.21 [-0.52 − 0.08] -0.02 [-0.29 − 0.26] R1 -0.16 [-0.40 − 0.09] 0.05 [-0.20 − 0.30] 0.11 [-0.17 − 0.38] 0.07 [-0.21 − 0.35] Lateral temporal BPND -0.24 [-0.50 − 0.03] -0.23 [-0.49 − 0.00] -0.35* [-0.64 − -0.10] -0.20 [-0.48 − 0.07] R1 -0.10 [-0.35 − 0.16] 0.20 [-0.03 − 0.43] 0.20 [-0.06 − 0.45] 0.24 [-0.02 − 0.49] Parietal BPND -0.22 [-0.53 − 0.10] -0.42†§ [-0.76 − -0.19] -0.30 [-0.71 − 0.00] -0.42†§ [-0.79 − -0.16] R1 -0.06 [-0.31 − 0.20] 0.18 [-0.03 − 0.40] 0.18 [-0.09 − 0.45] 0.26* [0.03 − 0.49] Occipital BPND -0.25 [-0.54 − 0.05] -0.23 [-0.52 − 0.04] -0.37*§ [-0.72 − -0.10] -0.30* [-0.62 − -0.02] R1 -0.00 [-0.27 − 0.26] 0.12 [-0.13 − 0.37] 0.13 [-0.15 − 0.41] 0.16 [-0.10 − 0.44] Frontal BPND -0.17 [-0.42 − 0.08] -0.37†§ [-0.69 − -0.18] -0.24 [-0.62 − 0.04] -0.33*§ [-0.68 − -0.09] R1 -0.23 [-0.48 − 0.01] 0.08 [-0.14 − 0.31] 0.10 [-0.17 − 0.37] 0.07 [-0.18 − 0.33] Models are adjusted for age, sex and education. Partial volume corrected [18F]flortaucipir BP ND and R1 were included in the model separately (model 1) and simultaneously (model 2). Standardized β’s with 95% confidence intervals are reported. BPND = non-displaceable binding potential. *p<0.05, †p<0.01, ‡p<0.001, §p FDR<0.05. 4
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