104 Chapter 4 Supplementary Table 3. Regional association between partial volume corrected [18F]flortaucipir BP ND (rows) and R1 (columns). [18F]flortaucipir R 1 Medial temporal Lateral temporal Parietal Occipital Frontal [18F]flortaucipir BP ND Medial temporal -0.07 [-0.29 – 0.15] -0.21 [-0.44 – 0.02] -0.22 [-0.46 – 0.02] -0.12 [-0.36 – 0.12] -0.11 [-0.34 – 0.13] Lateral temporal -0.12 [-0.35 – 0.10] -0.24 [-0.48 – 0.00] -0.26* [-0.51 − -0.02] -0.18 [-0.43 – 0.07] -0.07 [-0.31 – 0.17] Parietal 0.03 [-0.23 – 0.30] -0.17 [-0.33 – 0.20] -0.43†§ [-0.71 − -0.16] -0.38†§ [-0.66 − -0.10] 0.01 [-0.27 – 0.29] Occipital 0.00 [-0.25 – 0.25] -0.07 [-0.33 – 0.20] -0.33*§ [-0.59 − -0.07] -0.48‡§ [-0.73 − -0.24] 0.09 [-0.17 – 0.35] Frontal 0.10 [-0.13 – 0.34] -0.15 [-0.40 – 0.10] -0.25 [-0.50 – 0.01] -0.04 [-0.30 – 0.22] -0.04 [-0.29 – 0.21] Model is adjusted for age and sex. Standardized β’s with 95% confidence intervals are reported. Parametric [18F]flortaucipir images were partial volume corrected. BPND = non-displaceable binding potential. *p<0.05, †p<0.01, ‡p<0.001, §p FDR<0.05. Supplementary Table 4. Regional associations between partial volume corrected [18F]flortaucipir BP ND and R1 and cognition. Memory (n=71) Executive functioning (n=64) Language (n=59) Attention (n=64) Model 1 Medial temporal BPND -0.42†§ [-0.65 − -0.19] -0.12 [-0.36 – 0.12] -0.21 [-0.52 – 0.07] -0.02 [-0.23 – 0.25] R1 -0.12 [-0.39 – 0.14] 0.06 [-0.20 – 0.31] 0.12 [-0.17 – 0.40] 0.07 [-0.21 – 0.35] Lateral temporal BPND -0.21 [-0.47 – 0.04] -0.28*§ [-0.53 – -0.05] -0.39†§ [-0.68 – -0.14] -0.25 [-0.54 – 0.01] R1 -0.04 [-0.29 – 0.21] 0.25* [0.02 – 0.48] 0.27 [0.00 – 0.53] 0.28* [0.03 – 0.53] Parietal BPND -0.19 [-0.48 – 0.10] -0.49‡§ [-0.83 – -0.28] -0.36*§ [-0.76 – -0.07] -0.52‡§ [-0.89 – -0.28] R1 0.01 [-0.24 – 0.25] 0.30†§ [0.08 – 0.52] 0.26 [-0.01 – 0.52] 0.38†§ [0.13 – 0.60] Occipital BPND -0.24 [-0.51 – 0.02] -0.28*§ [-0.55 – -0.04] -0.42†§ [-0.75 – -0.17] -0.37†§ [-0.68 – -0.12] R1 0.09 [-0.15 – 0.34] 0.20 [-0.03 – 0.44] 0.26 [-0.01 – 0.53] 0.27* [0.03 – 0.54] Frontal BPND -0.16 [-0.42 – 0.10] -0.38†§ [-0.69 – -0.18] -0.25 [-0.63 – 0.03] -0.34†§ [-0.68 – -0.10] R1 -0.23 [-0.47 – 0.02] 0.11 [-0.13 – 0.35] 0.11 [-0.17 – 0.38] 0.10 [-0.16 – 0.37]
RkJQdWJsaXNoZXIy MjY0ODMw