Thesis

89 Efficacy and safety of deep brain stimulation for treatment-refractory anorexia nervosa: a systematic review and meta-analysis Supplementary table 2. Number of patients experiencing adverse events probably or possibly related to DBS as reported in the studies Villalba et al (N=8) Liu et al (N=28) Lipsman et al (N=16) Oudijn et al (N=4) Total / Mean (N=56) No adverse events 5 (62∙5%) 6 (21∙4%) 5 (31∙3%) 0 (0%) 16 (28∙6%) Cutaneous complications 3 (5∙4%) - 1 (1∙8%) - 4 (7∙1%) Pain at incision site (<4d) - 22 (39∙3%) - - 22 (39∙3%) Pain at incision site (>4d) - - 5 (8∙9%) - 5 (8∙9%) Intra-operative panic attack - - 1 (1∙8%) - 1 (1∙8%) Hypomanic/manic symptoms - - - 3 (5∙4%) 3 (5∙4%) Hypophosphatemia - - 1 (1∙8%) - 1 (1∙8%) Nausea - - 1 (1∙8%) - 1 (1∙8%) QT prolongation - - 1 (1∙8%) - 1 (1∙8%) Seroquel overdose - - 1 (1∙8%) - 1 (1∙8%) Increased lead impedance - - 1 (1∙8%) - 1 (1∙8%) Worsening mood - - 1 (1∙8%) - 1 (1∙8%) Refeeding delirium - - 1 (1∙8%) - 1 (1∙8%) Pancreatitis - - 1 (1∙8%) - 1 (1∙8%) Seizure - - 2 (3∙6%) 1*(1∙8%) 3 (5∙4%) *Auto-intoxication - - - 3 (5∙4%) 3 (5∙4%) *Self-destructive behavior - - - 2 (3∙6%) 2 (3∙6%) *Aggressive behavior - - - 1 (1∙8%) 1 (1∙8%) *Alcohol consumption - - - 1 (1∙8%) 1 (1∙8%) *Water intoxication - - - 2 (3∙6%) 2 (3∙6%) *Migraine - - - 1 (1∙8%) 1 (1∙8%) *Pain at battery site - - - 1 (1∙8%) 1 (1∙8%) *Severe auto mutilation - - - 1 (1∙8%) 1 (1∙8%) **Hyponatraemia - - 1 (1∙8%) - 1 (1∙8%) **Hypokalaemia - - 1 (1∙8%) - 1 (1∙8%)

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