88 Chapter 4 SUPPLEMENTARY MATERIAL Supplementary table 1. Study characteristics of included studies Villalba et al. (N=8) Liu et al. (N=28) Lipsman et al. (N=16) Oudijn et al. (N=4) Total / Mean (N=56) Mean age in years (range) 41 (SD = 16) 23 (SD = 4) 34 (SD = 8) 39 (SD = 10) 30 (18-57) Follow-up period 6 months 24 months 12 months 12 months* Mean illness duration in years 25 (SD = 11) 5 (3 – 10) 18 (SD = 6) 21 (SD = 3) 13 (SD = 9) Percentage female patients 87∙5% 100% 100% 100% 98∙2% Restrictive subtype 6 13 9 0 28 (50%) (Binge-)purging subtype 2 15 7 4 28 (50%) Suffering from psychiatric comorbidities (percentage) 8 (100%) 28 (100%) 14 (87∙5%) 4 (100%) 54 (96∙4%) MDD 7 (87∙5%) 12 (42∙9%) 12 (75%) 2 (50%) 33 (58∙9%) OCD 3 (37∙5%) 9 (32∙1%) 6 (37∙5%) 1 (25%) 19 (33∙9%) GAD / severe anxiety 0 7 (25%) 3 (18∙8%) 1 (25%) 11 (19∙6%) PTSD 0 0 10 (62∙5%) 0 10 (17∙9%) Panic disorder 3 (37∙5%) 0 0 0 3 (5∙4%) BPD 0 0 2 (12∙5%) 1 (25%) 3 (5∙4%) PD-NOS 0 0 0 3 (75%) 3 (5∙4%) SUD 0 0 1 (6∙3%) 1 (25%) 2 (3∙6%) No medication use 1 (12∙5%) 0 7 (43∙8%) 0 8 (14∙3%) 1 drug 4 (50%) 1 (3∙6%) 1 (6∙3%) 0 6 (10∙7%) 2 or 2> drugs 3 (37∙5%) 27 (96∙4%) 8 (50%) 4 (100%) 42 (75%) DBS Target NAcc (n=4) or SCC (n=4) NAcc SCC vALIC - BMI (kg/m3); average baseline 12∙67 (SD = 1∙64) 13∙01 (SD = 1∙86) 13∙83 (SD = 1∙49) 12∙44 (SD = 0∙52) 12∙99 (0∙61) BMI (kg.m3); post intervention** 13∙98 (SD = 2∙05) 17∙73 (SD = 3∙54) 17∙34 (SD = 3∙40) 17∙76 (SD = 2∙27) 16∙70 (1∙83) Y-BOCS; at baseline 16∙50 (SD = 7∙69) 20∙46 (SD = 8∙86) 27∙88 (SD = 8∙57) - 21∙61 (5∙78) Y-BOCS; post intervention ** 12∙75(SD = 11∙76) 13∙04 (SD = 9∙61) 19∙71 (SD = 10∙31) - 15∙17 (3∙94) HAM-A; at baseline 13∙63 (SD = 6∙30) 21∙39 (SD = 8∙54) - 29∙25 (SD = 2∙46) 21∙42 (7∙81) HAM-A; post intervention** 10∙94 (SD = 11∙84) 12∙63 (SD = 9∙18) - 15∙25 (SD = 1∙11) 12∙94 (2∙17) HAM-D; at baseline 15∙38 (SD = 5∙52) 26∙93 (SD = 11∙97) 19∙40 (SD = 6∙76) 27∙25 (SD = 2∙02) 22∙24 (5∙84) HAM-D; post intervention** 10∙50 (SD = 9∙87) 15∙93 (SD = 12∙33) 8∙79 (SD = 7∙64) 17∙25 (SD = 1∙67) 13∙12 (4∙11) Analyses PP PP PP PP - Abbreviations: N: number of subjects; AN: Anorexia Nervosa; DBS: Deep brain stimulation; MDD: Major depressive disorder; OCD: Obsessive-compulsive disorder; GAD: Generalized anxiety disorder; PTSD: Posttraumatic stress disorder; BPD: Borderline personality disorder; PD-NOS: Personality disorder not otherwise specified; SUD: Substance use disorder; NAcc: Nucleus accumbens; SCC: Subcallosal cingulate cortex; vALIC: Ventral anterior limb of the internal capsule; YBOCS: Yale-Brown Obsessive-Compulsive Scale; HAM-A: Hamilton Anxiety Rating Scale; HAM-D: Hamilton Depression Rating Scale; PP: per protocol. * After surgery DBS parameters were optimized for 3 weeks with DBS-off and a minimum of 12 weeks with DBS-ON. After optimization phase, the 12 months long maintenance phase followed after. ** The elapsed time for the variables measured after the intervention (BMI, Y-BOCS, HAM-A, HAM-D) is the same as the follow-up period.
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