79 Efficacy and safety of deep brain stimulation for treatment-refractory anorexia nervosa: a systematic review and meta-analysis Figure 1. Prisma flow diagram for included studies. Study characteristics Four included non-randomized non-controlled clinical trials contained a total of 56 participants. The follow-up period was either 6 (25), 12 (15, 33) or 24 months (4). The average age of the participants over all studies was 29 ∙ 8 years, with a range of 18–57 years. The mean illness duration over the four included studies was 12 ∙ 8 years. All but one of the participants were female. All patients were diagnosed with AN, with either the restrictive (n = 28) or the (binge-) purging subtype (n = 28). All participants were defined as treatment-refractory, which for instance included numerous hospital admissions and extensive psychiatric treatment. Most patients suffered from
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