55 Deep Brain Stimulation of the Ventral Anterior Limb of the Capsula Interna in Patients with Chronic Treatment-Refractory Anorexia Nervosa Table 2. DBS-induced changes in different parameters over time. T-1 T0 T1 T2 T3 T4 Baseline vs. End of follow-up t-value p-value Weight (kg) 34.03(±4.35) 34.48(±4.35) 33.38(±4.35) 43.18(±4.35) 45.91(±4.61) 47.88(±4.35)(P=.028) 40.70% 2.742 0.016* BMI (kg/m2) 12.44(±1.71) 12.70(±1.71) 12.28(±1.71) 15.91(±1.71) 17.01(±1.80) 17.76(±1.71)(P=.028) 42.80% 2.704 0.017* Systolic BP (mmHg) 104.25(±5,13) - 94,50 (±5,13) 102.00(±5,13) 109.50(±7.26) 132.00(±7.26)(P=.010) 26.62% 3.548 0.005** Diastolic BP (mmHg) 66.75(±6.38) - 61.00(±6.38) 72.50(±6.38) 73.91(±7.64) 87.41(±7.64)(P=.015) 30.95% 3.488 0.007** Body Temperature (⁰C) 35.63(±0.23) - 35.90(±0.23) 36.23(±0.23) 36.05(±0.33) 36.80(±0.33)(P=.014)- 30.32% 2.787 0.018* YBC-EDS Preoccupations 17.00(±1.07) - 17.00(±1.07) 15.50(±1.07) 13.25(±1.07)(P=.017) 14.25(±1.07) -16.20% -2.509 0.026* Rituals 18.50(±0.99) - 18.25(±0.99) 15.75(±0.99) 13.00(±0.99)(P=.003) 12.75(±0.99)(P=.002) -31.10% -4.483 0.001** Total 35.50(±1.96) - 35.25(±1.96) 31.25(±1.96) 26.25(±1.96)(P=.028) 27.00(±1.96)(P=.006) -23.90% -3.567 0.012* EDQOL Psychological 3.00(±0.20) - 3.33(±0.16) 2.53(±0.68) 3.20(±0.25) 2.88(±0.36) -4.00% -0.553 0.614 Physical/Cognitive 2.30(±0.31) - 2.45(±0.31) 1.58(±0.31) 1.48(±0.31) 1.15(±0.31)(P=.020) -50.00% -3.321 0.005** Financial 1.25(±0.31) - 1.45(±0.31) 1.65(±0.31) 0.55(±0.31) 1.00(±0.31) -20.00% -1.414 0.178 Work/School 2.85(±0.76) - 1.60(±0.76) 0.98(±0.76) 1.00(±0.76) 0.85(±0.76) -70.20% -1.750 0.104 Total 2.40(±0.32) - 2.63(±0.32) 2.38(±0.32) 2.30(±0.32) 1.83(±0.32) -23.80% -1.388 0.188 HAM-D 27.25(±2.09) - 18.25(±2.09)(P=.018) 19.00(±2.09)(P=.028) 15.25(±2.09)(P=.003) 17.25(±2.09)(P=.011) -36.70% -3.114 0.009** HAM-A 29.25(±2.17) - 17.25(±2.17)(P=.001) 16.75(±2.17)(P=.001) 16.50(±2.17)(P=.001) 15.25(±2.17)(P=.000) -47.90% -4.194 0.001** Linear mixed model analyses showed a significant linear effect of time on Weight (113.34±41.33, CI 95% 24.88-201.81, t=2.742, P=.016), BMI (43.16±15.96, CI 95% 9.07-77.25, t=2.704, P=.017), YBC-EDS Preoccupations (-9.25±3.69, CI 95% -17.22 - -1.28, t=-2.509, P=.026), YBC-EDS Rituals (-16.75±3.74, CI 95% -25.08 - -8.42, t=- 4.483, P=.001), YBC-EDS Total (-26.00±7.29, CI 95% -43.84 - -8.16, t=-3.567, P=.012), ED-QOL Physical/Cognitive (-3.28±0.99, CI 95% -5.38 - -1.17, t=-3.321, P=.005), HAM-D (-23.00±7.39, CI 95% -39.09 - -6.91, t=-3.114, P=.009) and HAM-A (-28.70±6.86, CI 95% -43.36 - -14.14, t=-4.194, P=.001)
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