179 Psychopathological and neurobiological overlap between anorexia nervosa and self-injurious behavior Figure 4 Conceptualization of the relationship between AN and NSSI via network analysis LIMITATIONS We described the (psychopathological and neurobiological) overlap between two distinct constructs: AN, which is a psychiatric diagnosis based on the internationally used psychiatric categorical classification system, and NSSI. NSSI has been included in the category ‘Conditions for Further Study’ in the DSM-5, suggesting a movement towards considering NSSI as a separate disorder. However, in the literature, NSSI is not studied as a separate disorder but as behavior occurring in patients with a range of (psychiatric) disorders as well as in patients with no disorder. Comparing two nosographically and conceptually different constructs may induce bias and complicates drawing conclusions on potential consistency. We have tried to minimize the risk of this bias by selecting literature on NSSI only, and excluding literature on self-destructive behavior and suicidality in general. Due to the use of various definitions of ‘self-destructive behavior’ or related terms, the differences in context in which self-destructive behavior is studied, and the conceptual nature of our literature synthesis, we conducted a narrative review. This narrative review may be a prelude to more systematic review with a formal search strategy related to the theories we formulated in this narrative review. Symptom 1 Neurobio 1 Symptom 3 Neurobio 3 Symptom 4 Neurobio 2 Symptom 2 Neurobio 4 Symptom 5 Symptom 6 AN NSSI
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