151 Endocrine and Metabolic Alterations following Deep Brain Stimulation in Anorexia Nervosa Table 2. Endocrine and metabolic markers in AN patients at four time points during follow-up. Axes T-1 (Screening) T2 T3 T4 F-value P-value Reference range Hypothalamicpituitary Hypothalamicpituitary-gonadal LH (mlU/mL) 6∙64 ± 6∙16 6∙64 ± 5∙69 6∙04 ± 4∙99 6∙95 ± 5∙34 2∙235 0∙218 Depends on phase of menstruation cycle FSH (mlU/mL) 15∙69 ± 12∙13 15∙89 ± 11∙53 14∙51 ± 10∙20 15∙32 ± 10∙75 0∙216 0∙881 Females 30-35 years 0.14 -13 µg/L Females 35-40 years < 11 µg/L Females >45 years < 0.48 µg/L *Testosteron (nmol/L) 0∙82 ± 0∙13 0∙83 ± 0∙13 0∙50 ± 0∙13 0∙64 ± 0∙13 4∙519 0∙034* Females 0.3 – 1.6 nmol/L Estradiol (pmol/L) 23∙86 ± 8∙08 67∙18 ± 26∙94 42∙86 ± 19∙97 69∙11 ± 48∙03 0∙910 0∙522 Depends on stimulation schedule Progesteron (nmol/L) 1∙13 ± 0∙42 0∙83 ± 0∙08 0∙71 ± 0∙07 0∙71 ± 0∙07 1∙530 0∙329 <3.3 nmol/L Prolactin (U/L) 0∙27 ± 0∙15 0∙31 ± 0∙20 0∙22 ± 0∙11 0∙16 ± 0∙06 0∙623 0∙634 <0.6 U/L premenopausal <0.4 U/L postmenopausal DHEAS (µmol/L) 2∙30 ± 0∙83 1∙41 ± 0∙28 1∙53 ± 0∙33 1∙19 ± 0∙23 1∙052 0∙451 Females 1 - 12 µmol/L Hypothalamicpituitary-adrenal ACTH (pmol/L) 5.41 ± 1.03 4.16 ± 0.20 6.15 ± 3.26 3.15 ± 0.43 2.238 0.307 <9pmol/L *Cortisol in plasma (nmol/L) 760∙25 ± 167∙27 615∙50 ± 51∙40 469∙25 ± 50∙09 400∙00 ± 105∙09 7∙50 0∙025* 250 - 650 nmol/L Hypothalamicpituitary-thyroid TSH (mE/L) 2∙53 ± 1∙10 2∙01 ± 0∙77 2∙83 ± 0∙98 1∙99 ± 0∙83 3∙577 0∙140 0.3 – 4.2 mE/L Free FT4 (pmol/L) 14∙08 ± 1∙56 13∙78 ± 1∙56 13∙38 ± 1∙56 16∙48 ± 1∙56 1∙729 0∙230 12.0 – 22.0 pmol/L T3 (nmol/L) 0∙96 ± 0∙25 1∙08 ± 0∙21 1∙10 ± 0∙12 1∙31 ± 0∙06 6∙51 0∙069 1.1 – 2.2 nmol/L Growth hormoneinsuline-likegrowth-factor-1 GH (mU/L) 15∙58 ± 3∙31 8∙94 ± 3∙31 9∙12 ± 3∙31 8∙72 ± 3∙31 1∙014 0∙421 Pulses to 20 mU/L (in females) IGF-1 (nmol/L) 11∙09 ± 2∙92 12∙78 ± 2∙92 18∙86 ± 2∙92 15∙65 ± 2∙92 1∙363 0∙301 Depends on age and gender Insulin (pmol/L) 24∙88 ± 10∙71 101∙83 ± 75∙06 34∙65 ± 17∙16 29∙08 ± 8∙89 1∙736 0∙315 12 - 96 pmol/L
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