150 Chapter 7 Primary outcomes of this study were published previously (5). A significant increase in BMI was found at the end of follow-up (5.32 kg/m2; +42.8%; P=.017). The increase in BMI was primarily seen in two of four patients (subject 2 and subject 3) (see figure 2). Figure 2. Time course of DBS-induced BMI (fixed effects ± SE). Linear mixed model analyses showed a significant linear effect of time on BMI (43.16±15.96, CI 95% 9.07-77.25, t=2.704, P=.017). This figure was originally published in Oudijn MS et al. Deep brain stimulation of the ventral anterior limb of the capsula interna in patients with treatment-refractory anorexia nervosa. Brain Stimul. 2021;14(6):1528-30 Endocrine and metabolic results The changes in endocrine and metabolic parameters over time and the mean changes at T4 compared to baseline are shown in table 2. The individual changes in each parameter are shown in supplement 2. We found a significant decrease in testosterone (21.47%; 0.18 ± 0.10 nmol/L, CI 95% -0.06 – 0.41, t = 1.705, P = .034) and cortisol (47.39%; 360.25 ± 125.17 nmol/L, CI 95% 27.29 – 693.21, t = 2.88, P = 0.025) over time. When analyzing the individual changes in each parameter (see supplement 2 and figure 2) the decrease in mean testosterone seems unrelated to the individual weight change. The decrease in cortisol seems more prominent in the weight-responders (subject 2 and 3) than in the non-responders.
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