149 Endocrine and Metabolic Alterations following Deep Brain Stimulation in Anorexia Nervosa continuous outcomes we reported fixed effects means and standard error (SE). Analysis was performed using linear mixed models. P-values of less than 0∙05 were considered significant. We present data for individual patients, also to observe possible relations with weight change. We applied imputation for non-detectable concentrations (4.65%) using the detection limit divided by √2 (20). Missing values (0.35%) were mostly due to insufficient sample volume at a certain time point for laboratory analyses. Possibly, low BMI contributed to low sample volumes drawn from patients. In line with previous research, to limit the number of tests needed to investigate fatty acid metabolism, we calculated the fatty acid chain length, unsaturation and peroxidability indices (20). RESULTS Patient demographics Four patients with treatment-refractory AN who underwent DBS of the vALIC, during 12 months follow-up, were included in this study. The mean age was 39 years, with a range of 32 to 53 years. The mean illness duration was 21 years (SD=3). All patients were female and suffered from bingepurging subtype of AN. Average BMI at baseline was 12.5 (SD=1.0) kg/m², indicating extremely severe AN. All patients suffered from psychiatric comorbidities. Two patients were diagnosed with personality disorder not otherwise specified (PD-NOS), one patient was diagnosed with major depressive disorder (MDD) and one patient was diagnosed with both PD-NOS and MDD. All demographic characteristics are shown in table 1. Table 1. Patient’s demographics. (BMI= Body Mass Index, f= female, GAD= Generalized Anxiety Disorder, OCD=Obsessive Compulsive Disorder, NOS= Not Otherwise Specified, SUD= Substance use disorder and BPD=Borderline Personality disorder) *The substance in question was alcohol, at screening this was in remission. ** Important to note that for purging this patient used ± 50 Bisacodyl. Sex Age at onset (years) Age at surgery (years) Illness duration (years) Anorexia Subtype BMI (screening) BMI (Historic low) Psychiatric comorbidities Psychiatric medication at surgery S1 f 15 32 18 Purging 12.4 9.5 GAD, Depression, Personality Disorder NOS Aripiprazole, Quetiapine, Oxazepam S2 f 15 39 24 Purging 11.2 10.2 SUD*, Personality Disorder NOS Aripiprazole, Quetiapine, Oxazepam S3 f 14 33 19 Purging** 13.4 10.6 Depression, OCD, BPD Venlafaxine, Clorazepate, Oxazepam, Temazepam S4 f 27 53 24 Purging 13.1 9.7 Personality Disorder NOS Citalopram, Alprazolam, Zolpidem Mean (SD) 18 (6) 39 (10) 21 (3) 12.5 (1.0) 10.0 (0.5)
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