Thesis

133 Electrophysiological effects of deep brain stimulation in anorexia nervosa Figure 7. Topography of wPLI connectivity. For each electrode, the connectivity in the alpha (left) and beta (right) bands are shown, averaged over each electrode’s connectivity with all other electrodes. Top three rows are for the three timepoints T1, T2, T4. Bottom row is for HC. Differences in connectivity between AN and HC Figure 5 also shows the connectivity spectra for HC (grey lines) averaged over the four regions. Most spectra showed clear peaks in the alpha band, and very often also in the (lower) beta band. For the alpha band, both coherence and wPLI showed increased alpha band connectivity comparing AN at T1 to HC. In the beta band, this effect (ANT1>HC) seemed stronger for wPLI (both posterior and anterior). Averaging over the frequency bands, coherence and wPLI in the alpha band were substantially increased for AN at T1 compared to HC. These did not reach significance for coherence, but reached significance for right-anterior channels (p= 0.0304). Beta showed small peaks in the coherence and wPLI spectra at T1, which was absent in HC. This reached nominal significance

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