129 Electrophysiological effects of deep brain stimulation in anorexia nervosa Figure 3. Within-subject changes in EEG alpha and beta power were highly significant in all patients. In patients 2-4 almost all channels showed significant effects. For patient 1, the FDR-adjusted p-values are shown converted to a positive scale (stronger effects are higher values) with -log10(p). Significance is reached at approximately -log10(0.05)=1.3. Figure 4 shows the change over time for the individual patients for the four regions anterior left (L) and right (R) and posterior left (L) and right (R). The general pattern that emerged was that most patients showed an initial reduction in alpha and beta power at T2 compared to baseline T1 and a subsequent increase at T4. To test whether these alpha and beta power changes over time were systematic across subjects we used the repeated-measures design. Nominally significant effects were observed for posterior L alpha (p=0.034) and anterior / posterior L beta (p=0.034 and p=0.013, respectively), however, multiple testing correction resulted in no significant effect across subjects for any region/frequency combination being found, indicating that the effects are still quantitatively heterogeneous across subjects.
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