111 Neural effects of deep brain stimulation on reward and loss anticipation and food viewing in anorexia nervosa: a pilot study d. Medial orbitofrontal cortex Figure 4. Significant interaction effects for reward anticipation for each anatomical region displayed at p<0.001, uncorrected (left) and corresponding bar plots displaying the contrast estimates for the interactions at the peak voxels (right). Table 2. Significant interaction effects for reward anticipation, pre- and post-DBS are compared for AN versus HC. The direction of the effect is illustrated by an increase or decrease for the AN group post-DBS. Anatomical region Time point Effect ↑ increase ↓ decrease Cluster size MNI-coordinates Statistics x y z Z-score p-value Precuneus R. Post-DBS AN ↓ 132 16 -44 60 3.99 0.035 Putamen R. Post-DBS AN ↓ 169 26 -10 16 4.69 0.025 VS R. Post-DBS AN ↓ N/A 8 0 -6 3.64 0.030* mOFC Post-DBS AN ↑ N/A -2 32 -22 3.55 0.043* * p-value after small volume correction (SVC) At baseline (pre-DBS), no significant differences for loss anticipation were found between AN and HC. However, significant group (AN and HC) by time (pre- and post-DBS) interactions were observed in the right precuneus (xyz = 10,-44,64; Z = 4.15; p-FWE = 0.007 ; cluster size = 222) and the right VS (xyz=12,-4,-4; Z=3.75; p-SVC=0.021) (See figure 5 and table 3). These interactions could both be explained by significantly lower activation for AN post-DBS compared to pre-DBS, while activations were higher in the HCs, especially in the right precuneus (xyz = 10,-44,64; Z = 4.15; p-FWE = 0.007 ; cluster size = 222) and right VS (xyz=12,-4,-4; Z=3.89; p-SVC=0.012).
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