Thesis

90 Chapter 4 ADCYAP1 0, 91 0, 93 0, 76 0, 75 0, 86 0, 64 0, 85 0, 78 0, 82 0, 80 0, 76 0, 62 0, 68 0, 64 0, 60 0, 06 0, 37 0, 39 0, 51 0, 57 0, 88 0, 83 0, 82 0, 93 0, 88 0, 81 0, 77 0, 90 0, 90 0, 86 0, 84 0, 87 0, 91 0, 75 0, 66 0, 57 0, 54 0, 57 0, 77 0, 56 0, 41 0, 42 0, 65 0, 55 0, 90 0, 40 0, 40 0, 22 0, 82 0, 47 0, 41 0, 41 0, 67 0, 64 0, 62 0, 48 0, 47 0, 51 0, 18 0, 60 0, 62 0, 62 0, 51 0, 06 0, 53 0, 06 0, 79 0, 06 0, 83 0, 45 0, 06 0, 56 0, 66 0, 63 0, 90 0, 74 0, 48 0, 64 0, 72 0, 53 0, 56 0, 49 0, 51 0, 88 0, 84 0, 06 0, 67 0, 65 1 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 1 0 0 1 1 0 1 0 0 1 1 0 0 0 0 1 1 0 0 1 0 0 1 1 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 0 0 BHLHE22 0, 98 0, 99 0, 87 0, 91 0, 94 0, 68 0, 93 0, 86 0, 92 0, 92 0, 86 0, 69 0, 69 0, 62 0, 69 0, 26 0, 66 0, 01 0, 40 0, 52 0, 63 0, 81 0, 91 0, 99 0, 97 0, 87 0, 86 0, 97 0, 97 0, 95 0, 94 0, 96 0, 91 0, 84 0, 65 0, 05 0, 41 0, 89 0, 84 0, 20 0, 74 0, 32 0, 47 0, 63 0, 62 0, 20 0, 86 0, 49 0, 98 0, 60 0, 85 0, 46 0, 55 0, 41 0, 96 0, 49 0, 59 0, 38 0, 37 0, 49 0, 53 0, 64 0, 40 0, 01 0, 06 0, 22 0, 76 0, 29 0, 96 0, 27 0, 54 0, 41 0, 62 0, 92 0, 95 0, 90 0, 27 0, 65 0, 77 0, 48 0, 67 0, 48 0, 43 0, 97 0, 96 0, 33 0, 83 0, 72 1 0 0 0 0 1 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CDH13 0, 99 1, 00 0, 92 0, 54 0, 98 0, 78 0, 98 0, 94 0, 97 0, 92 0, 88 0, 85 0, 72 0, 86 0, 78 0, 38 0, 68 0, 54 0, 36 0, 38 0, 99 0, 96 0, 98 0, 99 0, 98 0, 93 0, 94 0, 99 0, 99 0, 95 0, 98 0, 99 0, 84 0, 93 0, 84 0, 70 0, 52 0, 96 0, 92 0, 52 0, 14 0, 67 0, 75 0, 60 0, 93 0, 39 0, 60 0, 60 0, 45 0, 52 0, 60 0, 51 0, 77 0, 76 0, 43 0, 41 0, 56 0, 07 0, 53 0, 65 0, 43 0, 66 0, 44 0, 00 0, 36 0, 32 0, 95 0, 78 0, 98 0, 43 0, 00 0, 66 0, 69 0, 97 0, 82 0, 95 0, 47 0, 51 0, 83 0, 08 0, 44 0, 50 0, 56 0, 99 0, 98 0, 92 0, 57 0, 17 1 1 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CDO1 0, 98 0, 99 0, 79 0, 65 0, 94 0, 43 0, 94 0, 85 0, 86 0, 74 0, 59 0, 50 0, 35 0, 43 0, 56 0, 16 0, 32 0, 45 0, 39 0, 51 0, 97 0, 85 0, 89 0, 99 0, 94 0, 87 0, 63 0, 98 0, 98 0, 88 0, 95 0, 97 0, 98 0, 79 0, 50 0, 56 0, 16 0, 97 0, 65 0, 79 0, 98 0, 83 0, 98 0, 97 0, 97 0, 98 0, 98 0, 84 0, 80 0, 93 0, 49 0, 82 0, 39 0, 61 0, 99 0, 55 0, 56 0, 89 0, 83 0, 64 0, 76 0, 23 0, 19 0, 00 0, 20 0, 21 0, 97 0, 83 0, 95 0, 89 0, 54 0, 70 0, 74 0, 98 0, 95 0, 84 0, 97 0, 58 0, 78 0, 97 0, 48 0, 26 0, 49 0, 96 0, 97 0, 85 0, 93 0, 74 1 1 0 0 0 1 0 0 1 1 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 GALR1 0, 88 0, 91 0, 69 0, 05 0, 81 0, 57 0, 84 0, 75 0, 81 0, 74 0, 73 0, 65 0, 66 0, 63 0, 61 0, 35 0, 38 0, 48 0, 46 0, 56 0, 53 0, 77 0, 67 0, 91 0, 85 0, 76 0, 72 0, 88 0, 87 0, 84 0, 81 0, 86 0, 87 0, 75 0, 65 0, 49 0, 56 0, 49 0, 74 0, 51 0, 46 0, 46 0, 50 0, 33 0, 66 0, 44 0, 76 0, 46 0, 05 0, 39 0, 34 0, 68 0, 62 0, 62 0, 59 0, 54 0, 45 0, 48 0, 39 0, 56 0, 52 0, 49 0, 05 0, 05 0, 50 0, 40 0, 67 0, 64 0, 84 0, 39 0, 05 0, 45 0, 54 0, 46 0, 42 0, 52 0, 43 0, 57 0, 69 0, 05 0, 61 0, 39 0, 55 0, 71 0, 81 0, 66 0, 51 0, 55 1 1 0 0 0 1 0 0 1 1 0 1 1 0 1 0 0 1 1 1 0 0 1 1 0 0 0 1 0 0 1 0 1 0 0 0 0 0 1 0 0 0 1 1 1 1 0 0 0 0 1 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 GHSR 1, 00 1, 00 0, 92 0, 86 0, 99 0, 65 0, 98 0, 85 0, 97 0, 89 0, 80 0, 72 0, 65 0, 71 0, 57 0, 44 0, 36 0, 22 0, 34 0, 28 1, 00 0, 97 0, 99 1, 00 0, 98 0, 94 0, 93 1, 00 1, 00 0, 99 0, 99 0, 99 1, 00 0, 91 0, 78 0, 44 0, 39 1, 00 0, 94 0, 97 1, 00 0, 97 1, 00 1, 00 1, 00 1, 00 0, 98 0, 98 0, 98 0, 86 0, 79 0, 95 0, 74 0, 72 0, 99 0, 73 0, 68 0, 99 0, 53 0, 53 0, 50 0, 20 0, 33 0, 26 0, 28 0, 01 0, 99 0, 98 0, 99 0, 99 0, 90 0, 45 0, 20 1, 00 1, 00 0, 97 0, 99 0, 58 0, 95 0, 82 0, 57 0, 44 0, 04 1, 00 0, 99 0, 87 0, 96 0, 45 1 1 0 0 1 1 0 0 1 1 1 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 HAND2 0, 79 0, 82 0, 63 0, 65 0, 55 0, 28 0, 71 0, 64 0, 71 0, 61 0, 60 0, 51 0, 52 0, 57 0, 56 0, 34 0, 42 0, 49 0, 54 0, 51 0, 57 0, 50 0, 59 0, 78 0, 71 0, 67 0, 60 0, 78 0, 77 0, 56 0, 73 0, 75 0, 76 0, 64 0, 56 0, 46 0, 44 0, 50 0, 62 0, 52 0, 46 0, 45 0, 62 0, 45 0, 74 0, 44 0, 46 0, 51 0, 11 0, 41 0, 63 0, 11 0, 58 0, 58 0, 78 0, 48 0, 57 0, 65 0, 65 0, 48 0, 45 0, 49 0, 35 0, 11 0, 48 0, 49 0, 62 0, 49 0, 66 0, 43 0, 11 0, 44 0, 58 0, 51 0, 42 0, 49 0, 39 0, 54 0, 51 0, 11 0, 47 0, 49 0, 43 0, 76 0, 48 0, 68 0, 60 0, 60 1 1 0 0 0 1 1 0 1 1 0 0 1 0 0 0 0 0 1 1 0 0 1 1 0 0 0 1 1 0 1 0 0 0 1 0 0 0 1 1 0 0 1 1 0 1 1 0 0 1 1 1 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 1 0 0 0 0 0 1 0 0 1 SST 0, 50 0, 72 0, 39 0, 28 0, 61 0, 32 0, 68 0, 49 0, 66 0, 51 0, 50 0, 52 0, 50 0, 57 0, 51 0, 41 0, 50 0, 44 0, 52 0, 52 0, 49 0, 28 0, 41 0, 70 0, 51 0, 40 0, 42 0, 72 0, 72 0, 64 0, 67 0, 68 0, 64 0, 55 0, 52 0, 50 0, 50 0, 48 0, 32 0, 30 0, 38 0, 32 0, 56 0, 48 0, 68 0, 53 0, 50 0, 51 0, 61 0, 48 0, 48 0, 59 0, 55 0, 56 0, 71 0, 50 0, 51 0, 63 0, 50 0, 54 0, 50 0, 48 0, 49 0, 28 0, 51 0, 45 0, 62 0, 49 0, 64 0, 62 0, 28 0, 49 0, 51 0, 55 0, 54 0, 52 0, 58 0, 36 0, 63 0, 48 0, 53 0, 54 0, 49 0, 71 0, 65 0, 61 0, 53 0, 58 1 1 0 0 1 1 0 0 1 1 1 1 1 1 1 0 0 0 0 1 0 1 1 0 1 0 1 1 1 1 1 0 1 0 1 0 0 0 0 0 0 0 0 1 0 1 1 0 1 1 1 1 1 0 0 0 1 1 1 0 1 1 0 1 1 0 1 0 0 1 0 1 0 1 0 1 1 1 0 0 1 1 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 1 ZIC1 0, 88 0, 89 0, 57 0, 14 0, 47 0, 48 0, 82 0, 72 0, 71 0, 25 0, 66 0, 14 0, 60 0, 64 0, 65 0, 14 0, 50 0, 52 0, 54 0, 50 0, 84 0, 14 0, 75 0, 71 0, 80 0, 14 0, 67 0, 77 0, 86 0, 82 0, 82 0, 76 0, 80 0, 68 0, 55 0, 44 0, 14 0, 79 0, 51 0, 57 0, 14 0, 57 0, 69 0, 81 0, 86 0, 49 0, 65 0, 46 0, 14 0, 64 0, 48 0, 46 0, 63 0, 65 0, 79 0, 14 0, 51 0, 80 0, 72 0, 58 0, 51 0, 48 0, 49 0, 14 0, 60 0, 34 0, 81 0, 52 0, 81 0, 80 0, 54 0, 66 0, 48 0, 83 0, 81 0, 69 0, 83 0, 56 0, 69 0, 73 0, 37 0, 53 0, 34 0, 86 0, 83 0, 57 0, 74 0, 63 1 1 0 0 0 1 1 0 1 1 1 1 1 0 0 0 0 1 1 1 0 1 1 1 1 0 0 1 0 1 1 0 1 0 1 0 0 0 1 0 0 0 1 1 1 0 0 0 0 1 1 1 0 0 1 0 1 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 CDH13+GHSR+SST ADCYAP1 0, 65 0, 66 0, 61 0, 27 0, 63 0, 57 0, 58 0, 57 0, 61 0, 27 0, 57 0, 63 0, 59 0, 58 0, 27 0, 36 0, 52 0, 47 0, 52 0, 52 0, 65 0, 64 0, 59 0, 70 0, 66 0, 65 0, 64 0, 68 0, 58 0, 64 0, 66 0, 68 0, 63 0, 64 0, 63 0, 40 0, 46 0, 61 0, 59 0, 71 0, 67 0, 72 0, 69 0, 27 0, 59 0, 63 0, 58 0, 54 0, 27 0, 55 0, 27 0, 48 0, 61 0, 54 0, 59 0, 51 0, 27 0, 57 0, 39 0, 64 0, 52 0, 41 0, 27 0, 65 0, 46 0, 27 0, 45 0, 49 0, 55 0, 50 0, 52 0, 27 0, 56 0, 27 0, 62 0, 53 0, 51 0, 46 0, 49 0, 49 0, 45 0, 53 0, 35 0, 66 0, 27 0, 41 0, 51 0, 47 0, 52 0, 60 0, 52 0, 54 0, 55 0, 64 0, 27 0, 27 0, 57 0, 58 0, 63 0, 52 0, 55 0, 27 0, 27 0, 59 0, 48 0, 48 0, 59 0, 53 0, 45 0, 44 0, 59 0, 60 0, 45 0, 57 0, 51 0, 33 0, 45 0, 27 0, 27 0, 54 0, 57 0, 56 0, 49 0, 48 0, 55 0, 55 0, 56 0, 56 0, 43 0, 41 0, 53 0, 54 0, 49 0, 27 0, 49 0, 53 0, 52 0, 57 0, 27 0, 27 0, 51 0, 57 0, 46 0, 53 0, 48 0, 49 0, 27 0, 49 0, 53 0, 45 0, 47 0, 55 0, 52 0, 51 0, 55 0, 38 0, 44 0, 40 0, 47 0, 52 0, 41 0, 49 0, 55 0, 54 0, 27 0, 55 0, 52 0, 27 0, 50 0, 49 0, 45 0, 27 0, 54 0, 48 0, 54 0, 46 0, 27 0, 46 0, 55 0, 51 0, 54 0, 43 0, 48 0, 54 0, 27 0, 44 0, 27 0, 49 0, 27 0, 53 0, 51 0, 50 0, 50 0, 27 0, 53 0, 27 0, 51 0, 54 0, 27 0, 51 0, 27 0, 45 0, 47 0, 45 0, 49 0, 52 0, 27 0, 58 0, 27 0, 47 BHLHE22 0, 91 0, 92 0, 80 0, 38 0, 82 0, 60 0, 80 0, 64 0, 82 0, 87 0, 72 0, 89 0, 76 0, 60 0, 60 0, 33 0, 50 0, 33 0, 49 0, 21 0, 46 0, 85 0, 76 0, 97 0, 88 0, 89 0, 88 0, 93 0, 71 0, 90 0, 90 0, 95 0, 61 0, 89 0, 88 0, 43 0, 32 0, 83 0, 72 0, 98 0, 93 0, 95 0, 96 0, 56 0, 75 0, 32 0, 69 0, 48 0, 69 0, 66 0, 37 0, 35 0, 77 0, 77 0, 48 0, 59 0, 33 0, 35 0, 47 0, 59 0, 43 0, 63 0, 58 0, 96 0, 36 0, 64 0, 44 0, 40 0, 35 0, 71 0, 42 0, 57 0, 57 0, 21 0, 74 0, 54 0, 50 0, 08 0, 04 0, 50 0, 20 0, 46 0, 51 0, 90 0, 29 0, 20 0, 36 0, 41 0, 69 0, 69 0, 68 0, 54 0, 51 0, 85 0, 22 0, 01 0, 59 0, 59 0, 90 0, 64 0, 51 0, 22 0, 26 0, 71 0, 23 0, 25 0, 70 0, 54 0, 30 0, 46 0, 60 0, 71 0, 39 0, 38 0, 36 0, 42 0, 44 0, 39 0, 14 0, 44 0, 63 0, 65 0, 23 0, 39 0, 63 0, 55 0, 51 0, 50 0, 19 0, 31 0, 59 0, 30 0, 35 0, 27 0, 47 0, 52 0, 40 0, 50 0, 19 0, 36 0, 43 0, 53 0, 34 0, 37 0, 37 0, 45 0, 40 0, 45 0, 58 0, 33 0, 15 0, 48 0, 42 0, 48 0, 51 0, 29 0, 31 0, 01 0, 37 0, 49 0, 13 0, 48 0, 50 0, 51 0, 36 0, 44 0, 33 0, 28 0, 26 0, 27 0, 20 0, 30 0, 40 0, 41 0, 61 0, 47 0, 21 0, 26 0, 48 0, 46 0, 46 0, 48 0, 39 0, 33 0, 37 0, 38 0, 16 0, 30 0, 37 0, 52 0, 37 0, 38 0, 29 0, 16 0, 37 0, 31 0, 36 0, 49 0, 44 0, 32 0, 21 0, 16 0, 26 0, 22 0, 24 0, 26 0, 15 0, 72 0, 47 0, 30 CDH13 0, 68 0, 72 0, 64 0, 35 0, 66 0, 58 0, 61 0, 62 0, 64 0, 66 0, 60 0, 68 0, 63 0, 58 0, 54 0, 46 0, 43 0, 47 0, 51 0, 50 0, 69 0, 69 0, 63 0, 78 0, 69 0, 70 0, 67 0, 73 0, 60 0, 65 0, 72 0, 74 0, 52 0, 66 0, 69 0, 51 0, 32 0, 65 0, 59 0, 79 0, 71 0, 75 0, 71 0, 55 0, 57 0, 61 0, 56 0, 53 0, 52 0, 53 0, 16 0, 43 0, 63 0, 50 0, 16 0, 42 0, 16 0, 52 0, 48 0, 60 0, 50 0, 47 0, 16 0, 55 0, 46 0, 38 0, 54 0, 41 0, 44 0, 44 0, 16 0, 51 0, 59 0, 41 0, 64 0, 52 0, 41 0, 35 0, 49 0, 41 0, 43 0, 55 0, 41 0, 64 0, 16 0, 57 0, 48 0, 43 0, 58 0, 52 0, 47 0, 53 0, 48 0, 65 0, 16 0, 16 0, 57 0, 55 0, 68 0, 59 0, 55 0, 46 0, 41 0, 61 0, 25 0, 16 0, 60 0, 41 0, 36 0, 51 0, 63 0, 63 0, 48 0, 59 0, 50 0, 34 0, 39 0, 16 0, 42 0, 51 0, 54 0, 59 0, 31 0, 49 0, 55 0, 57 0, 52 0, 56 0, 46 0, 16 0, 55 0, 39 0, 47 0, 52 0, 47 0, 52 0, 50 0, 55 0, 36 0, 32 0, 53 0, 56 0, 34 0, 43 0, 45 0, 16 0, 45 0, 52 0, 49 0, 43 0, 34 0, 55 0, 51 0, 55 0, 55 0, 16 0, 43 0, 16 0, 55 0, 50 0, 35 0, 51 0, 55 0, 45 0, 47 0, 53 0, 53 0, 31 0, 47 0, 47 0, 40 0, 43 0, 50 0, 36 0, 54 0, 45 0, 47 0, 48 0, 54 0, 50 0, 53 0, 42 0, 46 0, 53 0, 31 0, 48 0, 25 0, 40 0, 34 0, 52 0, 48 0, 47 0, 40 0, 26 0, 56 0, 47 0, 48 0, 55 0, 51 0, 44 0, 44 0, 39 0, 43 0, 47 0, 47 0, 51 0, 40 0, 59 0, 47 0, 43 CDO1 1, 00 1, 00 0, 97 0, 55 0, 98 0, 58 0, 96 0, 79 0, 96 0, 98 0, 81 0, 99 0, 97 0, 56 0, 00 0, 10 0, 29 0, 34 0, 34 0, 12 0, 99 0, 99 0, 85 1, 00 1, 00 1, 00 0, 94 1, 00 0, 93 0, 99 1, 00 1, 00 0, 99 0, 99 0, 99 0, 16 0, 29 0, 96 0, 73 1, 00 1, 00 1, 00 1, 00 0, 49 0, 85 1, 00 0, 77 0, 40 0, 85 0, 66 0, 54 0, 67 0, 95 0, 83 0, 35 0, 99 0, 86 0, 98 0, 99 0, 99 1, 00 0, 97 0, 83 0, 99 1, 00 0, 40 0, 93 0, 37 0, 91 0, 99 0, 80 0, 63 0, 77 0, 98 0, 97 0, 37 0, 62 0, 21 0, 27 0, 60 0, 13 0, 95 0, 27 1, 00 0, 86 0, 83 0, 78 0, 95 0, 99 0, 92 0, 81 0, 98 0, 53 1, 00 1, 00 0, 04 0, 59 0, 90 0, 98 0, 86 0, 81 0, 40 0, 23 0, 84 0, 39 0, 60 0, 74 0, 76 0, 61 0, 40 0, 55 0, 58 0, 17 0, 55 0, 46 0, 19 0, 22 0, 23 0, 18 0, 49 0, 53 0, 50 0, 15 0, 41 0, 54 0, 35 0, 47 0, 33 0, 20 0, 18 0, 33 0, 41 0, 33 0, 38 0, 26 0, 28 0, 31 0, 30 0, 31 0, 24 0, 27 0, 32 0, 03 0, 44 0, 28 0, 49 0, 04 0, 30 0, 39 0, 07 0, 11 0, 25 0, 28 0, 23 0, 28 0, 45 0, 12 0, 40 0, 31 0, 22 0, 04 0, 28 0, 18 0, 19 0, 16 0, 23 0, 20 0, 13 0, 20 0, 09 0, 07 0, 13 0, 10 0, 13 0, 11 0, 23 0, 15 0, 05 0, 11 0, 07 0, 12 0, 11 0, 07 0, 08 0, 09 0, 08 0, 01 0, 01 0, 03 0, 06 0, 07 0, 02 0, 06 0, 01 0, 03 0, 05 0, 02 0, 05 0, 08 0, 04 0, 04 0, 04 0, 09 0, 01 0, 01 0, 01 0, 18 0, 01 0, 02 0, 00 GALR1 0, 72 0, 73 0, 66 0, 54 0, 66 0, 61 0, 61 0, 60 0, 66 0, 65 0, 61 0, 68 0, 65 0, 61 0, 58 0, 43 0, 46 0, 44 0, 50 0, 53 0, 44 0, 71 0, 54 0, 79 0, 72 0, 72 0, 67 0, 74 0, 67 0, 69 0, 74 0, 78 0, 66 0, 69 0, 70 0, 51 0, 41 0, 66 0, 62 0, 79 0, 73 0, 80 0, 78 0, 43 0, 57 0, 78 0, 60 0, 55 0, 59 0, 58 0, 41 0, 50 0, 64 0, 53 0, 45 0, 47 0, 11 0, 52 0, 41 0, 59 0, 44 0, 59 0, 11 0, 41 0, 45 0, 42 0, 58 0, 47 0, 33 0, 46 0, 34 0, 48 0, 55 0, 20 0, 66 0, 52 0, 55 0, 31 0, 47 0, 44 0, 47 0, 51 0, 45 0, 63 0, 54 0, 28 0, 38 0, 45 0, 51 0, 32 0, 11 0, 56 0, 54 0, 66 0, 11 0, 53 0, 59 0, 59 0, 50 0, 54 0, 53 0, 11 0, 41 0, 63 0, 41 0, 45 0, 62 0, 55 0, 40 0, 28 0, 62 0, 65 0, 48 0, 59 0, 50 0, 44 0, 38 0, 35 0, 30 0, 51 0, 58 0, 57 0, 53 0, 49 0, 55 0, 57 0, 56 0, 57 0, 27 0, 35 0, 57 0, 54 0, 49 0, 38 0, 47 0, 56 0, 53 0, 55 0, 43 0, 11 0, 53 0, 57 0, 39 0, 43 0, 48 0, 42 0, 31 0, 46 0, 49 0, 25 0, 41 0, 58 0, 53 0, 53 0, 57 0, 49 0, 42 0, 44 0, 51 0, 45 0, 11 0, 52 0, 54 0, 50 0, 37 0, 54 0, 49 0, 40 0, 49 0, 45 0, 33 0, 39 0, 52 0, 40 0, 52 0, 37 0, 40 0, 43 0, 53 0, 30 0, 47 0, 33 0, 45 0, 54 0, 22 0, 43 0, 39 0, 44 0, 41 0, 51 0, 44 0, 11 0, 45 0, 29 0, 51 0, 46 0, 43 0, 55 0, 47 0, 54 0, 19 0, 27 0, 43 0, 43 0, 47 0, 51 0, 11 0, 58 0, 11 0, 44 GHSR 0, 93 0, 93 0, 85 0, 04 0, 86 0, 64 0, 74 0, 63 0, 82 0, 85 0, 65 0, 89 0, 85 0, 63 0, 45 0, 34 0, 45 0, 34 0, 51 0, 31 0, 98 0, 92 0, 73 0, 98 0, 93 0, 92 0, 89 0, 96 0, 81 0, 93 0, 94 0, 96 0, 81 0, 90 0, 92 0, 51 0, 27 0, 82 0, 76 0, 99 0, 94 0, 99 0, 96 0, 75 0, 73 0, 92 0, 68 0, 84 0, 57 0, 56 0, 48 0, 39 0, 88 0, 78 0, 21 0, 92 0, 63 0, 87 0, 96 0, 94 0, 94 0, 77 0, 84 0, 96 0, 82 0, 68 0, 83 0, 34 0, 80 0, 77 0, 71 0, 17 0, 79 0, 39 0, 80 0, 37 0, 12 0, 15 0, 29 0, 53 0, 22 0, 80 0, 49 0, 64 0, 62 0, 83 0, 42 0, 62 0, 91 0, 88 0, 08 0, 88 0, 49 0, 96 0, 69 0, 00 0, 71 0, 49 0, 95 0, 68 0, 55 0, 15 0, 14 0, 79 0, 30 0, 04 0, 81 0, 50 0, 18 0, 03 0, 79 0, 81 0, 32 0, 67 0, 32 0, 19 0, 06 0, 36 0, 07 0, 47 0, 48 0, 53 0, 08 0, 29 0, 48 0, 59 0, 52 0, 65 0, 29 0, 41 0, 49 0, 35 0, 37 0, 04 0, 50 0, 67 0, 56 0, 51 0, 30 0, 14 0, 34 0, 63 0, 23 0, 13 0, 44 0, 09 0, 24 0, 33 0, 32 0, 22 0, 03 0, 63 0, 47 0, 49 0, 50 0, 04 0, 25 0, 11 0, 36 0, 35 0, 18 0, 32 0, 42 0, 45 0, 18 0, 46 0, 37 0, 24 0, 16 0, 36 0, 31 0, 06 0, 55 0, 22 0, 46 0, 08 0, 03 0, 17 0, 41 0, 33 0, 25 0, 23 0, 42 0, 46 0, 07 0, 11 0, 25 0, 13 0, 02 0, 29 0, 20 0, 29 0, 17 0, 10 0, 49 0, 31 0, 40 0, 28 0, 08 0, 33 0, 06 0, 06 0, 05 0, 23 0, 16 0, 27 0, 00 0, 14 0, 00 0, 31 HAND2 0, 72 0, 73 0, 64 0, 30 0, 50 0, 57 0, 59 0, 60 0, 64 0, 64 0, 60 0, 33 0, 53 0, 59 0, 48 0, 29 0, 37 0, 34 0, 51 0, 45 0, 46 0, 36 0, 52 0, 76 0, 69 0, 71 0, 64 0, 75 0, 62 0, 53 0, 73 0, 77 0, 64 0, 61 0, 69 0, 51 0, 42 0, 64 0, 60 0, 82 0, 73 0, 77 0, 78 0, 57 0, 55 0, 72 0, 44 0, 50 0, 44 0, 56 0, 44 0, 42 0, 63 0, 59 0, 12 0, 51 0, 24 0, 49 0, 41 0, 67 0, 49 0, 46 0, 41 0, 44 0, 43 0, 58 0, 37 0, 45 0, 59 0, 66 0, 47 0, 12 0, 55 0, 62 0, 65 0, 49 0, 57 0, 38 0, 43 0, 49 0, 33 0, 48 0, 37 0, 58 0, 43 0, 27 0, 43 0, 45 0, 49 0, 47 0, 43 0, 53 0, 53 0, 61 0, 25 0, 43 0, 56 0, 60 0, 69 0, 46 0, 56 0, 45 0, 39 0, 63 0, 42 0, 12 0, 62 0, 55 0, 43 0, 36 0, 62 0, 64 0, 43 0, 59 0, 49 0, 47 0, 40 0, 41 0, 42 0, 51 0, 53 0, 55 0, 41 0, 49 0, 53 0, 58 0, 54 0, 57 0, 46 0, 44 0, 56 0, 52 0, 52 0, 43 0, 50 0, 50 0, 52 0, 57 0, 39 0, 48 0, 51 0, 58 0, 26 0, 48 0, 50 0, 41 0, 42 0, 46 0, 54 0, 42 0, 20 0, 54 0, 53 0, 54 0, 55 0, 41 0, 44 0, 12 0, 52 0, 46 0, 32 0, 47 0, 58 0, 50 0, 48 0, 57 0, 51 0, 42 0, 44 0, 44 0, 39 0, 34 0, 52 0, 42 0, 52 0, 42 0, 45 0, 43 0, 54 0, 46 0, 43 0, 38 0, 47 0, 53 0, 42 0, 41 0, 39 0, 40 0, 39 0, 51 0, 42 0, 39 0, 40 0, 12 0, 54 0, 41 0, 46 0, 54 0, 36 0, 48 0, 32 0, 31 0, 42 0, 38 0, 44 0, 49 0, 48 0, 59 0, 48 0, 42 SST 0, 45 0, 62 0, 57 0, 43 0, 55 0, 57 0, 60 0, 54 0, 59 0, 23 0, 49 0, 61 0, 44 0, 56 0, 44 0, 43 0, 49 0, 35 0, 49 0, 52 0, 51 0, 49 0, 47 0, 68 0, 44 0, 63 0, 61 0, 69 0, 59 0, 60 0, 68 0, 65 0, 50 0, 29 0, 60 0, 50 0, 37 0, 54 0, 46 0, 66 0, 62 0, 58 0, 64 0, 61 0, 53 0, 61 0, 56 0, 52 0, 43 0, 46 0, 51 0, 49 0, 59 0, 49 0, 55 0, 55 0, 23 0, 55 0, 65 0, 60 0, 52 0, 47 0, 37 0, 67 0, 46 0, 40 0, 53 0, 52 0, 47 0, 63 0, 44 0, 41 0, 56 0, 47 0, 60 0, 51 0, 49 0, 48 0, 23 0, 49 0, 62 0, 49 0, 48 0, 56 0, 50 0, 48 0, 56 0, 50 0, 52 0, 42 0, 23 0, 54 0, 47 0, 66 0, 23 0, 43 0, 59 0, 53 0, 62 0, 45 0, 54 0, 38 0, 41 0, 62 0, 31 0, 43 0, 61 0, 56 0, 51 0, 23 0, 61 0, 62 0, 38 0, 56 0, 55 0, 44 0, 29 0, 48 0, 23 0, 52 0, 56 0, 55 0, 23 0, 49 0, 56 0, 53 0, 54 0, 56 0, 47 0, 48 0, 53 0, 47 0, 43 0, 40 0, 51 0, 58 0, 53 0, 58 0, 50 0, 42 0, 51 0, 54 0, 41 0, 46 0, 53 0, 47 0, 33 0, 47 0, 57 0, 39 0, 23 0, 53 0, 51 0, 54 0, 55 0, 51 0, 49 0, 23 0, 45 0, 45 0, 27 0, 50 0, 48 0, 53 0, 44 0, 52 0, 51 0, 50 0, 52 0, 50 0, 51 0, 51 0, 54 0, 47 0, 45 0, 46 0, 44 0, 43 0, 51 0, 46 0, 52 0, 51 0, 53 0, 55 0, 43 0, 43 0, 43 0, 40 0, 23 0, 45 0, 48 0, 45 0, 58 0, 23 0, 54 0, 51 0, 52 0, 50 0, 55 0, 48 0, 52 0, 41 0, 35 0, 43 0, 50 0, 45 0, 33 0, 60 0, 41 0, 45 ZIC1 0, 62 0, 61 0, 54 0, 53 0, 36 0, 54 0, 50 0, 52 0, 54 0, 33 0, 53 0, 55 0, 56 0, 57 0, 39 0, 46 0, 43 0, 46 0, 47 0, 50 0, 61 0, 33 0, 53 0, 49 0, 59 0, 51 0, 56 0, 55 0, 57 0, 62 0, 62 0, 57 0, 53 0, 53 0, 60 0, 41 0, 37 0, 54 0, 50 0, 60 0, 54 0, 68 0, 61 0, 33 0, 54 0, 36 0, 48 0, 54 0, 55 0, 51 0, 33 0, 50 0, 56 0, 39 0, 41 0, 47 0, 41 0, 52 0, 60 0, 61 0, 38 0, 51 0, 53 0, 55 0, 52 0, 33 0, 48 0, 44 0, 48 0, 53 0, 37 0, 33 0, 54 0, 56 0, 56 0, 49 0, 45 0, 45 0, 33 0, 52 0, 49 0, 54 0, 43 0, 59 0, 55 0, 52 0, 55 0, 50 0, 57 0, 54 0, 41 0, 58 0, 52 0, 60 0, 59 0, 47 0, 55 0, 52 0, 61 0, 52 0, 50 0, 33 0, 33 0, 58 0, 37 0, 33 0, 58 0, 55 0, 46 0, 33 0, 56 0, 59 0, 38 0, 55 0, 48 0, 37 0, 33 0, 43 0, 33 0, 52 0, 54 0, 54 0, 33 0, 49 0, 56 0, 52 0, 55 0, 54 0, 43 0, 45 0, 51 0, 51 0, 49 0, 40 0, 50 0, 54 0, 53 0, 53 0, 50 0, 44 0, 49 0, 56 0, 33 0, 50 0, 52 0, 50 0, 36 0, 51 0, 54 0, 39 0, 33 0, 55 0, 54 0, 53 0, 55 0, 47 0, 44 0, 50 0, 55 0, 51 0, 36 0, 54 0, 52 0, 53 0, 47 0, 55 0, 54 0, 48 0, 50 0, 49 0, 46 0, 43 0, 54 0, 50 0, 53 0, 50 0, 43 0, 43 0, 54 0, 49 0, 52 0, 51 0, 52 0, 53 0, 44 0, 46 0, 39 0, 33 0, 33 0, 50 0, 50 0, 44 0, 48 0, 33 0, 51 0, 51 0, 46 0, 51 0, 51 0, 53 0, 46 0, 46 0, 52 0, 47 0, 47 0, 49 0, 49 0, 55 0, 39 0, 48 CDO1+GHSR+ZIC1 ADCYAP1 0, 91 0, 87 0, 68 0, 57 0, 93 0, 70 0, 90 0, 74 0, 81 0, 72 0, 74 0, 84 0, 90 0, 65 0, 59 0, 19 0, 73 0, 35 0, 52 0, 30 0, 85 0, 49 0, 83 0, 93 0, 90 0, 88 0, 67 0, 93 0, 92 0, 89 0, 89 0, 95 0, 52 0, 95 0, 89 0, 71 0, 47 0, 76 0, 74 0, 89 0, 89 0, 96 0, 93 0, 92 0, 80 0, 94 0, 47 0, 70 0, 37 0, 63 0, 80 0, 36 0, 60 0, 79 0, 16 0, 37 0, 34 0, 34 0, 33 0, 93 0, 41 0, 25 0, 36 0, 73 0, 40 0, 04 0, 31 0, 64 0, 69 0, 65 0, 65 0, 42 0, 18 0, 16 0, 38 0, 31 0, 46 0, 45 0, 26 0, 71 0, 56 0, 68 0, 53 0, 96 0, 49 0, 60 0, 69 0, 18 0, 59 0, 83 0, 72 0, 26 0, 74 0, 52 0, 35 0, 43 0, 75 0, 75 0, 83 0, 72 0, 83 0, 33 0, 21 0, 37 0, 86 0, 01 0, 52 0, 72 0, 78 0, 57 0, 71 0, 69 0, 66 0, 01 0, 01 0, 50 0, 33 0, 11 0, 50 0, 23 0, 43 0, 66 0, 07 0, 69 0, 61 0, 31 0, 53 0, 50 0, 37 0, 19 0, 19 0, 61 0, 30 0, 60 0, 01 0, 60 0, 33 0, 01 0, 20 0, 27 0, 53 0, 33 0, 66 0, 03 0, 36 0, 04 0, 51 0, 19 0, 65 0, 49 0, 01 0, 30 0, 55 0, 33 0, 25 0, 58 0, 36 0, 40 0, 46 0, 49 0, 43 0, 50 0, 39 0, 58 0, 48 0, 01 0, 01 0, 01 0, 33 0, 07 0, 08 0, 46 0, 16 0, 36 0, 48 0, 27 0, 35 0, 45 0, 48 0, 52 0, 28 0, 33 0, 41 0, 01 0, 36 0, 18 0, 37 0, 33 0, 39 0, 44 0, 30 0, 54 0, 51 0, 17 0, 20 0, 36 0, 30 0, 42 0, 32 0, 10 0, 12 0, 28 0, 31 0, 39 0, 59 0, 01 0, 17 0, 19 0, 30 0, 39 0, 24 0, 28 0, 01 BHLHE22 0, 98 0, 96 0, 78 0, 53 0, 98 0, 85 0, 97 0, 90 0, 89 0, 85 0, 79 0, 97 0, 98 0, 50 0, 57 0, 10 0, 90 0, 15 0, 40 0, 47 0, 51 0, 38 0, 94 0, 99 0, 98 0, 97 0, 79 0, 99 0, 98 0, 97 0, 97 0, 99 0, 28 0, 99 0, 98 0, 76 0, 52 0, 89 0, 81 0, 98 0, 97 0, 99 0, 99 0, 51 0, 90 0, 88 0, 49 0, 58 0, 94 0, 66 0, 92 0, 29 0, 96 0, 94 0, 59 0, 66 0, 38 0, 31 0, 43 0, 60 0, 58 0, 74 0, 30 0, 83 0, 58 0, 75 0, 66 0, 57 0, 65 0, 96 0, 53 0, 89 0, 02 0, 12 0, 32 0, 84 0, 29 0, 41 0, 24 0, 79 0, 57 0, 36 0, 54 0, 99 0, 29 0, 44 0, 44 0, 18 0, 87 0, 75 0, 92 0, 12 0, 85 0, 63 0, 09 0, 40 0, 93 0, 55 0, 94 0, 88 0, 85 0, 34 0, 04 0, 71 0, 84 0, 33 0, 42 0, 72 0, 75 0, 54 0, 73 0, 65 0, 69 0, 16 0, 24 0, 52 0, 25 0, 33 0, 24 0, 09 0, 33 0, 50 0, 13 0, 60 0, 43 0, 33 0, 45 0, 32 0, 02 0, 50 0, 08 0, 56 0, 24 0, 49 0, 07 0, 58 0, 38 0, 36 0, 30 0, 36 0, 30 0, 12 0, 65 0, 19 0, 46 0, 31 0, 31 0, 14 0, 62 0, 19 0, 38 0, 40 0, 48 0, 11 0, 17 0, 35 0, 35 0, 36 0, 30 0, 39 0, 43 0, 34 0, 18 0, 47 0, 48 0, 27 0, 05 0, 18 0, 24 0, 12 0, 39 0, 34 0, 11 0, 20 0, 27 0, 30 0, 48 0, 22 0, 29 0, 54 0, 06 0, 47 0, 29 0, 03 0, 17 0, 10 0, 25 0, 15 0, 27 0, 33 0, 22 0, 30 0, 32 0, 18 0, 20 0, 25 0, 02 0, 17 0, 09 0, 07 0, 08 0, 05 0, 24 0, 27 0, 41 0, 04 0, 19 0, 11 0, 24 0, 17 0, 07 0, 16 0, 04 CDH13 0, 72 0, 68 0, 77 0, 53 0, 58 0, 47 0, 58 0, 58 0, 45 0, 41 0, 65 0, 11 0, 64 0, 76 0, 63 0, 11 0, 57 0, 50 0, 41 0, 72 0, 59 0, 76 0, 53 0, 53 0, 46 0, 56 0, 63 0, 46 0, 48 0, 56 0, 36 0, 52 0, 69 0, 58 0, 40 0, 42 0, 48 0, 45 0, 49 0, 42 0, 48 0, 74 0, 61 0, 55 0, 11 0, 49 0, 66 0, 72 0, 46 0, 27 0, 53 0, 38 0, 59 0, 79 0, 46 0, 35 0, 56 0, 73 0, 60 0, 50 0, 60 0, 51 0, 61 0, 66 0, 45 0, 55 0, 48 0, 59 0, 67 0, 74 0, 40 0, 30 0, 30 0, 44 0, 42 0, 51 0, 41 0, 71 0, 59 0, 46 0, 46 0, 40 0, 34 0, 68 0, 78 0, 66 0, 38 0, 37 0, 66 0, 26 0, 11 0, 39 0, 44 0, 59 0, 71 0, 63 0, 68 0, 46 0, 72 0, 36 0, 55 0, 55 0, 44 0, 49 0, 68 0, 41 0, 45 0, 62 0, 63 0, 52 0, 62 0, 61 0, 54 0, 24 0, 11 0, 46 0, 44 0, 49 0, 45 0, 44 0, 49 0, 58 0, 46 0, 60 0, 52 0, 45 0, 47 0, 37 0, 54 0, 42 0, 36 0, 58 0, 46 0, 52 0, 11 0, 54 0, 34 0, 54 0, 45 0, 51 0, 47 0, 47 0, 57 0, 33 0, 43 0, 26 0, 49 0, 45 0, 57 0, 50 0, 45 0, 46 0, 56 0, 41 0, 42 0, 54 0, 41 0, 46 0, 46 0, 45 0, 48 0, 49 0, 53 0, 51 0, 53 0, 36 0, 35 0, 35 0, 40 0, 38 0, 37 0, 48 0, 38 0, 48 0, 50 0, 51 0, 43 0, 49 0, 53 0, 48 0, 43 0, 45 0, 45 0, 43 0, 44 0, 43 0, 44 0, 45 0, 47 0, 49 0, 40 0, 47 0, 48 0, 41 0, 34 0, 49 0, 42 0, 45 0, 42 0, 42 0, 35 0, 40 0, 39 0, 40 0, 49 0, 38 0, 38 0, 40 0, 11 0, 45 0, 11 0, 43 0, 36 CDO1 1, 00 0, 99 0, 79 0, 40 1, 00 0, 80 1, 00 0, 93 0, 96 0, 84 0, 86 0, 99 1, 00 0, 37 0, 34 0, 72 0, 93 0, 26 0, 15 0, 04 1, 00 0, 12 0, 98 1, 00 1, 00 0, 99 0, 61 1, 00 1, 00 0, 97 1, 00 1, 00 0, 13 1, 00 1, 00 0, 87 0, 12 0, 94 0, 72 1, 00 1, 00 1, 00 1, 00 1, 00 0, 96 1, 00 0, 35 0, 74 0, 98 0, 41 0, 98 1, 00 0, 99 0, 99 0, 94 0, 99 0, 99 0, 97 0, 96 1, 00 1, 00 0, 99 0, 96 0, 43 1, 00 0, 52 0, 99 1, 00 0, 57 1, 00 0, 93 0, 98 1, 00 0, 98 0, 95 0, 86 0, 98 0, 66 0, 23 0, 97 0, 95 0, 99 0, 92 1, 00 0, 97 1, 00 0, 99 1, 00 0, 99 0, 98 0, 94 1, 00 0, 97 0, 82 1, 00 0, 89 1, 00 0, 99 0, 98 0, 98 0, 98 0, 96 0, 05 0, 88 0, 88 0, 26 0, 74 0, 72 0, 67 0, 71 0, 58 0, 57 0, 40 0, 15 0, 25 0, 17 0, 36 0, 43 0, 42 0, 09 0, 46 0, 39 0, 04 0, 30 0, 36 0, 08 0, 22 0, 25 0, 15 0, 09 0, 03 0, 20 0, 13 0, 22 0, 30 0, 16 0, 32 0, 06 0, 02 0, 10 0, 13 0, 08 0, 14 0, 13 0, 13 0, 13 0, 10 0, 06 0, 13 0, 11 0, 04 0, 10 0, 08 0, 13 0, 11 0, 09 0, 06 0, 03 0, 08 0, 09 0, 07 0, 10 0, 04 0, 09 0, 09 0, 02 0, 02 0, 07 0, 07 0, 08 0, 05 0, 06 0, 05 0, 03 0, 05 0, 02 0, 04 0, 03 0, 03 0, 03 0, 02 0, 03 0, 03 0, 01 0, 03 0, 01 0, 03 0, 02 0, 02 0, 02 0, 02 0, 02 0, 02 0, 03 0, 02 0, 01 0, 00 0, 02 0, 02 0, 02 0, 01 0, 00 0, 01 0, 01 0, 01 0, 00 0, 00 0, 00 0, 00 0, 00 0, 00 0, 00 0, 00 GALR1 0, 64 0, 64 0, 66 0, 55 0, 32 0, 49 0, 59 0, 54 0, 44 0, 39 0, 61 0, 18 0, 58 0, 67 0, 59 0, 37 0, 54 0, 52 0, 36 0, 45 0, 46 0, 53 0, 52 0, 54 0, 44 0, 54 0, 38 0, 51 0, 48 0, 55 0, 36 0, 59 0, 53 0, 59 0, 46 0, 41 0, 45 0, 42 0, 51 0, 48 0, 46 0, 67 0, 54 0, 58 0, 46 0, 51 0, 60 0, 64 0, 52 0, 43 0, 44 0, 27 0, 50 0, 72 0, 42 0, 47 0, 43 0, 67 0, 58 0, 48 0, 52 0, 55 0, 55 0, 59 0, 44 0, 42 0, 53 0, 57 0, 66 0, 65 0, 46 0, 51 0, 35 0, 44 0, 18 0, 51 0, 44 0, 62 0, 51 0, 55 0, 46 0, 48 0, 43 0, 63 0, 72 0, 59 0, 47 0, 45 0, 61 0, 42 0, 18 0, 45 0, 40 0, 46 0, 65 0, 53 0, 61 0, 18 0, 66 0, 58 0, 50 0, 52 0, 44 0, 49 0, 62 0, 47 0, 46 0, 57 0, 59 0, 56 0, 55 0, 54 0, 52 0, 18 0, 42 0, 42 0, 53 0, 46 0, 52 0, 41 0, 53 0, 54 0, 48 0, 56 0, 52 0, 47 0, 50 0, 45 0, 50 0, 47 0, 42 0, 52 0, 40 0, 52 0, 46 0, 52 0, 54 0, 50 0, 37 0, 49 0, 47 0, 45 0, 54 0, 43 0, 40 0, 29 0, 51 0, 36 0, 53 0, 49 0, 44 0, 44 0, 55 0, 49 0, 47 0, 53 0, 44 0, 45 0, 46 0, 48 0, 47 0, 53 0, 52 0, 50 0, 53 0, 44 0, 39 0, 38 0, 42 0, 42 0, 42 0, 49 0, 43 0, 49 0, 50 0, 48 0, 46 0, 49 0, 51 0, 46 0, 42 0, 43 0, 48 0, 41 0, 45 0, 43 0, 55 0, 49 0, 47 0, 47 0, 49 0, 51 0, 49 0, 41 0, 45 0, 47 0, 45 0, 47 0, 47 0, 48 0, 45 0, 43 0, 45 0, 43 0, 47 0, 39 0, 32 0, 45 0, 40 0, 46 0, 33 0, 27 0, 47 GHSR 0, 99 0, 94 0, 62 0, 35 0, 99 0, 72 0, 94 0, 71 0, 88 0, 60 0, 63 0, 94 0, 99 0, 45 0, 22 0, 09 0, 83 0, 11 0, 27 0, 22 0, 99 0, 22 0, 93 0, 99 0, 96 0, 95 0, 68 0, 99 0, 98 0, 98 0, 97 0, 99 0, 16 1, 00 0, 98 0, 71 0, 12 0, 74 0, 67 0, 96 0, 95 1, 00 0, 98 1, 00 0, 85 0, 99 0, 24 0, 78 0, 81 0, 64 1, 00 0, 90 0, 98 0, 95 0, 84 0, 95 0, 95 0, 90 0, 93 1, 00 1, 00 0, 82 0, 91 0, 84 0, 86 0, 57 0, 95 0, 75 0, 70 0, 88 0, 75 0, 91 0, 98 0, 27 0, 73 0, 70 0, 38 0, 32 0, 05 0, 85 0, 44 0, 94 0, 97 1, 00 0, 90 1, 00 0, 22 0, 44 0, 95 0, 95 0, 86 0, 99 0, 69 0, 66 0, 67 0, 70 0, 93 0, 27 0, 96 0, 81 0, 94 0, 67 0, 03 0, 33 0, 89 0, 04 0, 14 0, 83 0, 78 0, 47 0, 73 0, 57 0, 65 0, 01 0, 38 0, 02 0, 20 0, 04 0, 56 0, 16 0, 65 0, 62 0, 04 0, 61 0, 44 0, 20 0, 32 0, 24 0, 74 0, 05 0, 03 0, 57 0, 04 0, 53 0, 00 0, 57 0, 16 0, 07 0, 03 0, 06 0, 24 0, 23 0, 62 0, 10 0, 22 0, 05 0, 33 0, 16 0, 52 0, 47 0, 02 0, 07 0, 47 0, 01 0, 11 0, 53 0, 06 0, 18 0, 14 0, 17 0, 22 0, 39 0, 23 0, 34 0, 27 0, 03 0, 00 0, 06 0, 14 0, 12 0, 08 0, 19 0, 10 0, 08 0, 42 0, 18 0, 09 0, 17 0, 26 0, 27 0, 06 0, 14 0, 12 0, 01 0, 11 0, 01 0, 34 0, 16 0, 26 0, 22 0, 26 0, 65 0, 24 0, 08 0, 05 0, 08 0, 00 0, 22 0, 07 0, 53 0, 01 0, 04 0, 00 0, 07 0, 27 0, 05 0, 06 0, 12 0, 12 0, 07 0, 00 0, 04 0, 08 HAND2 0, 64 0, 59 0, 57 0, 54 0, 31 0, 47 0, 55 0, 53 0, 37 0, 56 0, 59 0, 29 0, 60 0, 67 0, 58 0, 46 0, 49 0, 49 0, 42 0, 46 0, 66 0, 51 0, 50 0, 57 0, 42 0, 55 0, 37 0, 56 0, 43 0, 57 0, 29 0, 54 0, 70 0, 44 0, 39 0, 53 0, 48 0, 61 0, 56 0, 46 0, 44 0, 68 0, 53 0, 62 0, 18 0, 47 0, 59 0, 64 0, 51 0, 43 0, 41 0, 58 0, 49 0, 71 0, 42 0, 46 0, 67 0, 68 0, 57 0, 18 0, 53 0, 44 0, 62 0, 59 0, 47 0, 44 0, 48 0, 56 0, 46 0, 67 0, 45 0, 33 0, 39 0, 32 0, 59 0, 50 0, 42 0, 36 0, 59 0, 46 0, 45 0, 44 0, 55 0, 51 0, 71 0, 55 0, 45 0, 39 0, 60 0, 22 0, 42 0, 46 0, 37 0, 47 0, 67 0, 52 0, 49 0, 43 0, 65 0, 48 0, 47 0, 54 0, 45 0, 48 0, 64 0, 24 0, 43 0, 58 0, 58 0, 53 0, 58 0, 56 0, 53 0, 39 0, 37 0, 47 0, 50 0, 49 0, 51 0, 42 0, 56 0, 54 0, 45 0, 56 0, 52 0, 47 0, 45 0, 43 0, 52 0, 49 0, 42 0, 55 0, 44 0, 51 0, 46 0, 51 0, 40 0, 50 0, 45 0, 48 0, 47 0, 44 0, 55 0, 43 0, 45 0, 45 0, 50 0, 32 0, 54 0, 49 0, 35 0, 46 0, 54 0, 49 0, 47 0, 52 0, 43 0, 47 0, 45 0, 48 0, 48 0, 51 0, 51 0, 52 0, 52 0, 46 0, 43 0, 47 0, 44 0, 43 0, 40 0, 49 0, 44 0, 48 0, 50 0, 43 0, 45 0, 48 0, 49 0, 48 0, 42 0, 44 0, 49 0, 42 0, 45 0, 46 0, 50 0, 47 0, 49 0, 48 0, 44 0, 55 0, 49 0, 41 0, 40 0, 48 0, 43 0, 47 0, 43 0, 41 0, 40 0, 42 0, 43 0, 40 0, 50 0, 43 0, 42 0, 42 0, 45 0, 43 0, 39 0, 35 0, 45 SST 0, 36 0, 85 0, 53 0, 31 0, 83 0, 56 0, 79 0, 54 0, 86 0, 41 0, 27 0, 84 0, 38 0, 71 0, 35 0, 62 0, 35 0, 30 0, 44 0, 34 0, 42 0, 06 0, 50 0, 82 0, 39 0, 79 0, 45 0, 91 0, 89 0, 81 0, 89 0, 91 0, 22 0, 27 0, 85 0, 49 0, 23 0, 56 0, 68 0, 64 0, 73 0, 62 0, 73 0, 40 0, 83 0, 74 0, 60 0, 63 0, 67 0, 53 0, 63 0, 61 0, 73 0, 55 0, 35 0, 45 0, 35 0, 29 0, 77 0, 90 0, 47 0, 52 0, 47 0, 77 0, 45 0, 49 0, 82 0, 75 0, 66 0, 85 0, 66 0, 71 0, 78 0, 73 0, 63 0, 59 0, 57 0, 52 0, 28 0, 67 0, 39 0, 61 0, 75 0, 81 0, 59 0, 62 0, 70 0, 65 0, 65 0, 20 0, 22 0, 57 0, 67 0, 32 0, 23 0, 56 0, 70 0, 40 0, 69 0, 66 0, 79 0, 24 0, 20 0, 55 0, 78 0, 01 0, 57 0, 64 0, 60 0, 56 0, 71 0, 69 0, 60 0, 09 0, 01 0, 32 0, 27 0, 49 0, 43 0, 35 0, 59 0, 65 0, 19 0, 68 0, 67 0, 32 0, 31 0, 05 0, 33 0, 19 0, 11 0, 70 0, 32 0, 60 0, 42 0, 61 0, 61 0, 55 0, 23 0, 41 0, 43 0, 48 0, 65 0, 28 0, 18 0, 44 0, 49 0, 31 0, 49 0, 57 0, 28 0, 35 0, 48 0, 50 0, 51 0, 63 0, 37 0, 34 0, 39 0, 35 0, 32 0, 67 0, 34 0, 55 0, 22 0, 24 0, 33 0, 38 0, 43 0, 23 0, 27 0, 46 0, 29 0, 45 0, 48 0, 58 0, 48 0, 41 0, 46 0, 25 0, 23 0, 49 0, 44 0, 30 0, 24 0, 29 0, 73 0, 44 0, 51 0, 36 0, 44 0, 57 0, 46 0, 58 0, 04 0, 44 0, 16 0, 50 0, 33 0, 59 0, 21 0, 26 0, 31 0, 14 0, 46 0, 43 0, 24 0, 24 0, 34 0, 29 0, 01 0, 01 0, 17 ZIC1 0, 90 0, 83 0, 41 0, 46 0, 30 0, 59 0, 79 0, 66 0, 73 0, 32 0, 55 0, 63 0, 87 0, 69 0, 56 0, 26 0, 60 0, 32 0, 37 0, 02 0, 79 0, 17 0, 64 0, 21 0, 78 0, 44 0, 58 0, 73 0, 85 0, 88 0, 85 0, 81 0, 33 0, 84 0, 89 0, 55 0, 28 0, 52 0, 61 0, 46 0, 60 0, 96 0, 82 0, 62 0, 77 0, 25 0, 47 0, 58 0, 73 0, 47 0, 63 0, 81 0, 78 0, 68 0, 62 0, 26 0, 45 0, 26 0, 71 0, 90 0, 55 0, 58 0, 22 0, 54 0, 61 0, 34 0, 46 0, 69 0, 52 0, 63 0, 69 0, 63 0, 85 0, 75 0, 55 0, 50 0, 60 0, 46 0, 50 0, 66 0, 35 0, 71 0, 60 0, 92 0, 76 0, 81 0, 86 0, 36 0, 68 0, 51 0, 61 0, 87 0, 70 0, 42 0, 74 0, 51 0, 80 0, 61 0, 80 0, 67 0, 70 0, 60 0, 03 0, 44 0, 81 0, 02 0, 47 0, 76 0, 73 0, 65 0, 66 0, 65 0, 45 0, 02 0, 02 0, 14 0, 39 0, 61 0, 53 0, 06 0, 67 0, 70 0, 02 0, 66 0, 67 0, 08 0, 38 0, 36 0, 38 0, 14 0, 02 0, 62 0, 27 0, 63 0, 15 0, 59 0, 66 0, 21 0, 04 0, 36 0, 44 0, 28 0, 62 0, 27 0, 42 0, 21 0, 46 0, 22 0, 66 0, 52 0, 15 0, 42 0, 51 0, 51 0, 44 0, 58 0, 25 0, 15 0, 42 0, 46 0, 39 0, 57 0, 32 0, 62 0, 65 0, 08 0, 09 0, 33 0, 40 0, 44 0, 26 0, 57 0, 31 0, 35 0, 53 0, 32 0, 44 0, 42 0, 49 0, 44 0, 21 0, 36 0, 42 0, 16 0, 41 0, 10 0, 51 0, 38 0, 44 0, 40 0, 43 0, 48 0, 56 0, 53 0, 28 0, 44 0, 02 0, 45 0, 42 0, 54 0, 26 0, 06 0, 20 0, 32 0, 48 0, 19 0, 09 CDH13+CDO1+ZIC1 Self-sample Scrape Endometrial cancer patients Controls Paired samples Unpaired samples EEC SEC CCEC UCS MC US Grade 1 Grade 2 Grade 3 Urine Methylation level: Classification: negative positive High Low Figure 3: DNA methylation of single markers ADCYAP1, BHLHE22, CDH13, CDO1, GALR1, GHSR, HAND2, SST, and ZIC1 and optimal marker panels for endometrial cancer detection in urine, cervicovaginal self-samples, and clinician-taken cervical scrapes. Paired samples of cancers are stratified per histological category. In the Mixed carcinoma (MC) category, the first column represents a mixed endometrioid and clear-cell carcinoma and the last two columns are mixed clear-cell and serous carcinomas. Methylation levels (row) are shown per sample (column) and visualized using predicted probabilities on a two-color gradient from green (low methylation level; predicted probability of 0) to red (high methylation level; predicted probability of 1). Black boxes represent methylation positive samples detected using the optimal marker panel (i.e. classified as case by multivariable logistic regression using predicted probability thresholds of ≥0.40 for urine, ≥0.46 for self-samples, and ≥0.34 for scrapes). CCEC, Clear cell endometrial carcinoma; EEC, Endometrioid endometrial carcinoma; MC, Mixed carcinoma; SEC, Serous endometrial carcinoma; UCS, Uterine carcinosarcoma; US, Uterine sarcoma.

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