TABLE OF CONTENTS Chapter 1 General introduction 9 Part 1 Endometrial and ovarian cancer detection in patient-friendly samples Chapter 2 Non-invasive detection of endometrial cancer by DNA methylation analysis in urine Clinical Epigenetics. 12, 1, p. 165. (2020) 31 Chapter 3 DNA methylation markers for endometrial cancer detection in minimally invasive samples: a systematic review Epigenomics. 12:18, 1661-1672. (2020) 49 Chapter 4 DNA methylation testing for endometrial cancer detection in urine, cervicovaginal self-samples and cervical scrapes International Journal of Cancer. 153(2): 341-351. (2023) 77 Chapter 5 Molecular analysis for ovarian cancer detection in patientfriendly samples medRxiv. 2023.09.28.23296279. (2023) 109 Part 2 Non-small cell lung cancer detection in urine Chapter 6 Detection of non-metastatic non-small cell lung cancer in urine by methylation-specific PCR analysis: a feasibility study Lung Cancer. 170:156-64. (2022) 149 Chapter 7 Dynamics of methylated cell-free DNA in the urine of nonsmall cell lung cancer patients Epigenetics. Oct 4:1-13. (2021) 175 Chapter 8 Summary and general discussion 205 Appendices Dutch summary | Nederlandse samenvatting 238 List of contributing authors 242 PhD portfolio 244 List of publications 246 About the author | Curriculum Vitae 248 Cover design description 249 Acknowledgements | Dankwoord 250
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