79 DNA methylation testing for endometrial cancer detection in patient-friendly sample types GRAPHICAL ABSTRACT NOVELTY AND IMPACT Endometrial cancer incidence is rising and current diagnostic approaches often require invasive biopsy procedures. Here, the authors compared the diagnostic value of endometrial cancer detection by DNA methylation testing between paired urine samples, cervicovaginal self-samples and clinician-taken cervical scrapes. Endometrial cancer detection in samples collected by home-based methods was excellent and comparable to diagnostic performance in clinician-taken cervical scrapes. The results demonstrated the value of methylation analysis in patient-friendly sample types for detection of endometrial cancer of all stages. The approach has great potential to noninvasively screen patient populations at risk for endometrial cancer. 4
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