74 Chapter 3 Supplementary Table Supplementary Table 1: Study designs of the selected studies. Study (year) Study type (sample type) Case and control selection Presenting symptoms Timing of minimally invasive sampling BakkumGamez (2015) Discovery (tissue) and validation (swabs) Prospective Abnormal bleeding† Prior to hysterectomy Chang (2018) Test (scrapes) Retrospective U Prior to surgery Doufekas (2013) Discovery (tissue) and validation (swabs) Prospective Postmenopausal bleeding Prior to surgery Huang (2017) Discovery (TCGA data) and validation (scrapes) U U U Jones (2013) Discovery (tissue) and validation (swabs) Prospective Postmenopausal bleeding Prior to hysteroscopy, endometrial biopsy or hysterectomy Liew (2019) Validation (scrapes) Retrospective Abnormal bleeding Prior to surgery Sangtani (2020) Validation (tampons) Prospective U Prior to hysterectomy De Strooper (2014) Test (scrapes) Retrospective U During cervical screening program or when attending an outpatient clinic‡ Wentzensen (2014) Discovery (TCGA data) and validation (endometrial brush) Prospective U Prior to hysterectomy †Presenting symptoms only described for cases. ‡Leftover material from population-based cervical screening or attending a gynecological outpatient clinic. TCGA = The Cancer Genome Atlas; U = unknown.
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