37 Non-invasive detection of endometrial cancer by DNA methylation analysis in urine Table 1: Patient characteristics. Healthy controls n 46 Age: median 56 Age: min - max 45 - 82 Endometrial cancer cases n 42 Age: median 66 Age: min - max 40 − 86 Histology n % Endometrioid 23 54.8 Grade 1 8 Grade 2 7 Grade 3 8 Serous 11 26.2 Carcinosarcoma 4 9.5 Clear cell 1 2.4 Mixed* 3 7.1 FIGO stage n % I 27 64.3 II 3 7.1 III 7 16.7 IV 5 11.9 *Patients with endometrial carcinomas of mixed subtypes included two mixed clear cell and endometrioid carcinomas, and one mixed serous and carcinosarcoma. Table 2: DNA quality characteristics of paired urine fractions of controls and EC patients (n = 76). Full void urine Urine sediment Urine supernatant Median Cq Invalid (%) Median Cq Invalid (%) Median Cq Invalid (%) ACTB 24.7 2 (2.6) 24.8 0 (0.0) 26.1 2 (2.6) EC: endometrial cancer. Invalid (%): invalid for methylation analysis based on a Cq value for ACTB ≥ 32. 2
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