249 Cover design description COVER DESIGN DESCRIPTION To me, science is like completing a puzzle without an example. Each piece of the puzzle symbolizes a new discovery. Along the way, we aim to connect these pieces to gradually reveal the bigger picture of our understanding. Unraveling the exact shape of a puzzle piece takes time and requires patience. In some cases, the form of these puzzle pieces might be surprisingly different from what we expect. The process of scientific exploration might even reshape what we thought we knew to provide a better fit with new findings. Completing a puzzle is rewarding. However, in science, there are puzzles we might never fully complete and understand. Some puzzle pieces fit well enough to advance and broaden current knowledge, but may still contain internal gaps that we cannot fill in yet. The colors represent the different sample types used for patient-friendly cancer detection. Blue stands for the color of the brush used by clinicians to collect cervical scrape material. Pink refers to the color of the brush used by women to collect vaginal material at home. The knowledge gained from cancer detection using these brushes have laid the foundation for cancer detection in urine. The yellow puzzle pieces symbolize the ongoing process of piecing together information for urine-based cancer detection. Every new discovery gets us one step closer to completing the puzzle and creating new solutions for patient-friendly cancer detection. A
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