203 Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients Supplementary Table 2: Parameter estimates of DNA methylation levels of CDO1, SOX17 and TAC1 measured in NSCLC patients (n=23) and controls (n=60) according to the fitted linear mixed model. CDO1 SOX17 TAC1 Fixed effects Estimates 95%-CI p Estimates 95%-CI p Estimates 95%-CI p (Intercept) 0.76 (0.48, 1.04) 1.41 (1.24, 1.59) 0.44 (0.35, 0.53) casecontrol [control] -0.05 (-0.34, 0.23) 0.711 -0.26 (-0.50, -0.03) 0.030 -0.14 (-0.28, 0.01) 0.059 sex [male]* 0.30 (0.03, 0.57) 0.031 Random Effects σ2 0.19 0.24 0.17 τ00 subject 0.27 0.14 0.02 ICC 0.59 0.38 0.10 N subject 83 83 83 Observations** 193 193 193 DNA methylation level estimates are presented as square root transformed ct ratios. σ2 = within-subject variability; τ00 = between-subject variability; ICC = Intraclass Correlation Coefficient; NSCLC = non-small cell lung cancer. *Only CDO1 methylation levels were corrected for sex, following backward stepwise selection. **Five urine samples of patients were excluded from the analysis based on an ACTB Ct value of ≥ 32. 7
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