Thesis

201 Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients Supplementary Figure ** 0.0 2.5 5.0 7.5 10.0 12.5 case control Methylation level (square root ct ratio) CDO1 a * 0.0 2.5 5.0 7.5 10.0 12.5 case control Methylation level (square root ct ratio) SOX17 b ** 0.0 2.5 5.0 7.5 10.0 12.5 case control Methylation level (square root ct ratio) TAC1 c Supplementary Figure 1: Methylation levels of CDO1 (a), SOX17 (b), and TAC1 (c) measured in 11 pairs of tumors and adjacent normal tissues from NSCLC patients. Methylation levels are normalized to the reference gene ACTB and presented as square root Ct ratios. Outliers are indicated by bold circles located outside the whiskers of the boxplot. Statistical significance was computed using the nonparametric paired samples Wilcoxon test. *p < 0.10 (suggestive evidence), **p < 0.05 (moderate evidence). 7

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