199 Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients Final models are displayed below: # Response variable Final model 5 CDO1 methylation level lmer(CDO1sqrt ~ casecontrol + gender + (1|subject), data = URIC_R_ allDT) 6 SOX17 methylation level lmer(SOX17sqrt ~ casecontrol + (1|subject), data = URIC_R_allDT) 7 TAC1 methylation level lmer(TAC1sqrt ~ casecontrol + (1|subject), data = URIC_R_allDT) Testing model assumptions The assumptions of linearity, normality of the residuals and random effects, and homoscedasticity (i.e. constant variance of the residuals) were checked visually. A series of diagnostic plots were computed using the ‘sjPlot’ package to check these assumptions. #5 – CDO1 methylation levels in cases vs. controls 7
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