164 Chapter 6 Acknowledgments The authors would like to thank the URIC biobank team for their assistance. Funding This work was supported by the Cancer Center Amsterdam Foundation; Edli Foundation; and Weijerhorst Foundation. Funders only provided financial support for the conduct of the research or had no role in conducting the research and preparation of the manuscript. This research did not receive any other specific grants from funding agencies in the public or commercial sectors. Disclosure of interest RS has a minority stake in Self-screen B.V., a spin-off company of VU University Medical Center Amsterdam. SB, RS, IB, and GK are named inventors on patent applications related to the detection of methylated DNA in urine. All other authors have no conflict of interest to declare. Author Contributions SB, IB, and RS designed the study. SB recruited patients, collected clinical samples, and clinical data. IB and CD guided and provided the collection of clinical samples. BW, DW, and AH were involved in the design and optimization of the multiplex methylation assay. BW, SB, MT, TB, and DW performed laboratory work. RS supervised laboratory experiments. BW, SB, and BL-W carried out statistical analyses. BW, SB and RS drafted the first version of the manuscript. All authors contributed to the interpretation of the data and revised the manuscript critically. Funding was acquisitioned by GK, IB, and RS. All authors approved the final version of the manuscript.
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