160 Chapter 6 Follow up time (days) Methylation level (square root Ct ratio) 5 6 7 8 9 10 11 12 13 14 CDO1 SOX17 0 3 3 First sample 0 Surgery Second sample 581 End of follow up 624 CDO1 SOX17 0 3 15 First sample 0 Surgery Second sample 324 End of follow up 386 CDO1 SOX17 0 3 2 First sample 0 Surgery Second sample 280 End of follow up 351 CDO1 SOX17 0 3 2 First sample 0 Surgery Second sample 252 Incomplete resection (R1) 302 CT-scan No residual disease on imaging 74 117 Radiotherapy 344 End of follow up CDO1 SOX17 0 3 2 First sample 0 Surgery Second sample 225 End of follow up 293 CDO1 SOX17 0 3 1 First sample 0 Surgery Second sample 974 End of follow up 1007 CDO1 SOX17 0 3 10 First sample 0 Surgery Second sample 336 End of follow up 386 CDO1 SOX17 0 3 0 First sample 8 Surgery Second sample 285307 Recurrence End of follow up 383 SOX17 CDO1 0 3 17 First sample 0 Surgery Second sample 253 End of follow up 350 CDO1 SOX17 0 3 3 First sample 0 Surgery Second sample 66 End of follow up 168 CDO1 SOX17 Figure 5: Pre- and postoperative methylation levels of CDO1 and SOX17 for the detection of disease recurrence. Methylation levels of CDO1 (circles) and SOX17 (triangles) measured before (first sample) and 63-974 days after (second sample) surgery. Moments of sampling, presence of ------->
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