140 Chapter 5 0.42 0.35 0.59 0.42 0.48 0.42 0.15 0.55 0.15 0.53 −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 C2CD4D CDO1 GHSR MAL C2CD4D CDO1 GHSR MAL Scrape and full void urine 0.44 0.4 0.45 0.44 0.32 0.44 −0.02 0.33 −0.02 0.33 −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 C2CD4D CDO1 GHSR MAL C2CD4D CDO1 GHSR MAL Scrape and urine supernatant 0.4 0.16 0.8 0.4 0.5 0.4 0.15 0.7 0.15 0.36 −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 C2CD4D CDO1 GHSR MAL C2CD4D CDO1 GHSR MAL Scrape and urine sediment 0.59 0.53 0.52 0.59 0.58 0.59 0.37 0.32 0.37 0.61 −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 C2CD4D CDO1 GHSR MAL C2CD4D CDO1 GHSR MAL Full void urine and urine supernatant 0.69 0.81 0.67 0.69 0.5 0.69 0.7 0.67 0.7 0.76 −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 C2CD4D CDO1 GHSR MAL C2CD4D CDO1 GHSR MAL Full void urine and urine sediment 0.68 0.42 0.32 0.68 0.38 0.68 0.28 0.29 0.28 0.65 −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 C2CD4D CDO1 GHSR MAL C2CD4D CDO1 GHSR MAL Urine sediment and urine supernatant Supplemental Figure 7: The Spearman’s rank correlation coefficients (r) of methylation markers C2CD4D, CDO1, GHSR, and MAL between paired samples of 23 women diagnosed with ovarian cancer. The Spearman’s rank correlation coefficient was calculated based on 2log-transformed Cq ratios. Circle color and size indicate the degree of correlation (i.e. the larger and darker the circle, the more correlation).
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