139 Molecular analysis for ovarian cancer detection in patient-friendly samples p = 0.86 −10 −5 0 5 10 C2CD4D p = 0.79 CDO1 p = 0.072 GALR1 p = 0.26 −10 −5 0 5 10 GHSR p = 0.54 MAL p = 0.15 NRN1 p = 0.51 −10 −5 0 5 10 PRDM14 p = 0.0097 0.012 1 SST p = 0.028 0.318 0.192 ZIC1 diagnosis Control Benign Malignant Cervicovaginal self−sample DNA methylation level (2log transformed Cq value) Supplemental Figure 6: DNA methylation levels of C2CD4D, CDO1, GALR1, GHSR, MAL, NRN1, PRDM14, SST, and ZIC1 in self-collected cervicovaginal samples of healthy controls (n=40), and women diagnosed with a benign (n=25) or high-stage malignant ovarian mass (n=28). Violin plots represent medians with lower and upper quartile and range whiskers. DNA methylation levels are shown by 2log-transformed Cq ratios. A p-value of <0.05 was considered statistically significant. Cq = quantification cycle. 5
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