137 Molecular analysis for ovarian cancer detection in patient-friendly samples p = 0.29 −10 −5 0 5 10 C2CD4D p = 0.26 −10 −5 0 5 10 CDO1 p = 0.41 −10 −5 0 5 10 GALR1 p = 0.012 0.018 0.024 −10 −5 0 5 10 GHSR p = 0.0502 −10 −5 0 5 10 MAL p = 0.28 −10 −5 0 5 10 NRN1 p = 0.79 −10 −5 0 5 10 PRDM14 p = 0.56 −10 −5 0 5 10 SST p = 0.31 −10 −5 0 5 10 ZIC1 diagnosis Control Benign Malignant Urine sediment DNA methylation level (2log transformed Cq value) Supplemental Figure 4: DNA methylation levels of C2CD4D, CDO1, GALR1, GHSR, MAL, NRN1, PRDM14, SST, and ZIC1 in urine sediment of healthy controls (n=30), and women diagnosed with a benign (n=27) or high-stage malignant ovarian mass (n=29). DNA methylation levels are shown by 2log-transformed Cq ratios. Violin plots represent medians with lower and upper quartile and range whiskers. A p-value of <0.05 was considered statistically significant. Cq = quantification cycle. 5
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