124 Chapter 5 Acknowledgements The authors thank dr. Poell, dr. Kasius, and dr. Mom for the useful discussions and support during funding acquisition. The authors also thank dr. Y. Kim, J.M.P Egthuijsen, N. Hogervorst, and N. Evander for technical assistance and A. Koch for help during sample collection. Funding information This research was funded by the CCA Foundation and Maarten van der Weijden Foundation, who provided financial support for the conduct of the research and had no role in conducting the research and preparation of the manuscript. RvdH was funded by the Weijerhorst Foundation. NM and FM were funded by the Dutch Cancer Society (grant number KWF: 12822). Ethics statement All patients participating in the SOLUTION1 study were 18 years or older and signed informed consent before sample collection. Ethical approval was obtained by the Medical Ethical Committee of the VU University Medical Center for the use of samples collected within the SOLUTION1 study (METc: 2016.213, Trial registration ID: NL56664.029.16), samples stored in the URIC biobank (TcB 2018.657), and samples archived in the biobank containing leftover material of the Dutch national cervical cancer screening program (TcB 2020.245). The Code of Conduct for Responsible Use of Left-over Material of the Dutch Federation of Biomedical Scientific Societies was adhered for the use of tissue specimen. Data and code availability The sequencing dataset generated and analyzed during the current study is available in the European Genome-Phenome Archive repository, under accession number EGAD00001010848. The DNA methylation dataset generated and analyzed during this study is available from the corresponding author on reasonable request. Conflict of interest statement RS has a minority share in Self-screen B.V., a spin-off company of Amsterdam UMC, location VUmc. Self-screen B.V. holds patents and products related to the work. RS and FM are co-inventors on multiple patents related to methylation markers and cfDNA analysis, respectively. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
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