111 Molecular analysis for ovarian cancer detection in patient-friendly samples GRAPHICAL ABSTRACT Release of ovarian cancer fragments by local shedding or transrenal excretion Collection of ovarian cancer-derived DNA by patient-friendly methods DNA methylation analysis Elevated methylation levels in cervical scrapes and urine of ovarian cancer patients vs. healthy controls Urine copy number analysis Copy number aberrations detected in urine samples of ovarian cancer patients Methylation level Control Cancer Cancer Control Cervical scrape Cervicovaginal self-sample Urine Created with BioRender.com. HIGHLIGHTS • Ovarian cancer is often diagnosed at an advanced stage with a poor prognosis • We studied the potential of molecular testing in different types of patient-friendly material for ovarian cancer detection • Elevated methylation of ovarian cancer-associated genes can be measured in cervical scrapes and urine • Copy number aberrations are detectable in urine of ovarian cancer patients • DNA-based testing in cervical scrapes and urine could aid ovarian cancer diagnosis upon further development 5
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