105 DNA methylation testing for endometrial cancer detection in patient-friendly sample types Supplementary Table 1: Youden’s Index (J) thresholds for maximal sensitivity and specificity calculations of individual markers and marker panels. Urine Self-sample Scrape ADCYAP1 0.59 0.57 0.62 BHLHE22 0.59 0.54 0.50 CDH13 0.42 0.55 0.43 CDO1 0.50 0.57 0.55 GALR1 0.53 0.58 0.53 GHSR 0.57 0.55 0.52 HAND2 0.44 0.51 0.62 SST 0.56 0.58 0.51 ZIC1 0.63 0.54 0.46 CDH13+GHSR+SST 0.40 - - CDO1+GHSR+ZIC1 - 0.46 - CDH13+CDO1+ZIC1 - - 0.34 Thresholds represent predicted probability values. 4
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