30 Part I Chapter 2 Abstract Purpose The radionuclide bone scan is the cornerstone of skeletal nuclear medicine imaging. Bone scintigraphy is a highly sensitive diagnostic nuclear medicine imaging technique that uses a radiotracer to evaluate the distribution of active bone formation in the skeleton related to malignant and benign disease, as well as physiologic processes. Methods The European Association of Nuclear Medicine (EANM) has written and approved these guidelines to promote the use of nuclear medicine procedures with high quality. Conclusion The present guideline offers assistance to nuclear medicine practitioners in optimizing the diagnostic procedure and interpreting bone scintigraphy. This guideline describes the protocols that are currently accepted and used routinely, but does not include all existing procedures. They should therefore not be taken as exclusive of other nuclear medicinemodalities that can be used to obtain comparable results. It is important to remember that the resources and facilities available for patient care may vary.