25 General introduction and outline of this thesis 18. Ahuja K, Sotoudeh H, Galgano SJ, Singh R, Gupta N, Gaddamanugu S, et al. (18)F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities. J Nucl Med Technol. 2020;48(1):9-16. 19. Park PSU, Raynor WY, Sun Y, Werner TJ, Rajapakse CS, Alavi A. (18)F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications. Int J Mol Sci. 2021;22(12). 20. Lasnon C, Coudrais N, Houdu B, Nganoa C, Salomon T, Enilorac B, et al. How fast can we scan patients with modern (digital) PET/CT systems? Eur J Radiol. 2020;129:109144. 1