Thesis

159 Quantifying skeletal burden in fibrous dysplasia using Sodium Fluoride PET/CT Table 1. Patient characteristics Parameter Value Number of patients (n) 20 Female 14 Age at scan (years) mean (SD*) 46 (14.1) range 16-68 Dose (MBq) median (IQR**) 69.0 (63.3-82.0) range 58.0-101.0 Massic Dose (MBq/kg) median (IQR**) 0.97 (0.92-1.04) range 0.75-1.83 Body Mass Index, BMI (kg/m2) median (IQR**) 26.2 (22.4-29.0) range 18.8-33.8 Incubation (min) median (IQR**) 49 (44 - 91) range 36-150 Biochemistry ALP (IU/L); median (IQR**) 101 (76-138) P1NP (ng/mL); median (IQR**) 78 (38-202) CTX (ng/mL); median (IQR**) 0.40 (0.16-0.66) FGF-23 (RU/mL); median (IQR**) n=16 136 (103-184) Imaging parameters Skeletal burden score, SBS median (IQR**) 15.8 (2.5-17.6) range 18.8-33.8 Cut-off SUV (g/mL) median (IQR**) 8.7 (7.3-9.5) range 4.1-13.7 SUVpeak (g/mL) mean (SD*) 27.9 (11.0) range 3.7-48.7 Total Lesion Fluoride uptake, TLF (g) median (IQR**) 2,187 (753-10,172) range 0***-17,665 Clinical parameters Brief Pain Inventory, BPI Average; median (IQR**) n=15 5,0 (2.0-7.0) Bisphosphonates use, n (%) 18 (90) * SD = Standard deviation ** IQR = Inter Quartile Range *** Total Lesion Fluoride (TLF) was zero in one patient as the maximal uptake in FD was below the cut-off 6

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