74 Chapter 5 Results Patient characteristics Fifty-two patients (58%) were 52 male, mean age was 65 ±11 years. In total, 17/90 patients (19%) had a poor response with predominant tumour at histopathology (pTRG 4-5) and 73/90 patients (81%) showed predominant fibrosis (pTRG 1-3). Final ypT-stage after surgery (or W&W) was ypT0 in n=27, ypT1-2 in n=22, ypT3 in n=37 and ypT4 in n=4 patients. Table 1 Patient characteristics N= % Total 90 100% Mean age (± SD) 65 (± 11) Sex Male 52 58% Female 38 42% Baseline stage (MRI) cT-stage cT1-2 3 3% cT3 68 76% cT4 18 20% cN-stage cN0 12 13% cN1 19 21% cN2 59 66% Final response (pathology) ypT-stage ypT0* 27 30% ypT1 5 6% ypT2 17 19% ypT3 37 41% ypT4 4 4% TRG pTRG1* 27 30% pTRG2 17 19% pTRG3 29 32% pTRG4 15 17% pTRG5 2 2% * based on histology after surgery in 21 patients and on a sustained clinical complete response during W&W with >2 years of clinical follow up in the remaining 6 patients (which was used as a surrogate endpoint to define a yT0 / TRG 1)
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