124 Chapter 7 Table 2 Patient characteristics N= % Patients N=90 90 100% Median age (ranges) 64.5 (41-82) Sex Male 52 58% Female 38 42% Baseline clinical stage as reported on MRI cT-stage cT1-2 3 3% cT3 68 76% cT4 18 20% cN-stage cN0 12 13% cN1 19 21% cN2 59 66% Final response yT-stage yT0* 27 30% yT1-2 22 24% yT3 37 41% yT4 4 4% yN-stage yN0* 65 72% yN1 17 19% yN2 8 9% TRG TRG1* 27 30% TRG2 17 19% TRG3 29 32% TRG4 15 17% TRG5 2 2% Response categorization (Near-)complete response (TRG1-2)* 44 49% Incomplete response (TRG3-5) 46 51% * based on histology after surgery in 21 patients and on a sustained clinical complete response during W&W with >2 years of clinical follow up in the remaining 6 patients
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