Thesis

107 Comparison of MRI response evaluation methods in rectal cancer: a multicentre and multireader validation study 6 Supplement 2 Tables detailing the impact of readers experience level (S2A) and image quality (S2B) on diagnostic performance, including effects sizes, 95% confidence intervals and levels of significance. Table S2A Effects of reader experience level on diagnostic performance Sensitivity Specificity PPV NPV Accuracy mrTRG Expert 55% 78% 54% 80% 71% Non-expert 58% 60% 41% 77% 59% Effect size (+ 95% CI) and level of significance (p) 0.03 (-0.13;0.18) p=0.7 -0.18(-0.36;-0.005) p=0.06 -0.14(-0.22;-0.05) p=0.005 -0.03(-0.096;0.03) p=0.3 -0.12(-0.21;-0.02) p=0.02 modTRG Expert 34% 90% 63% 76% 73% Non-expert 42% 76% 46% 75% 66% Effect size (+ 95% CI) and level of significance (p) 0.08(-0.07;0.23) p=0.3 -0.14(-0.25;-0.03) p=0.02 -0.17(-0.28;-0.06) p=0.007 -0.01(-0.05;0.04) p=0.7 -0.07(-0.14;-0.008) p=0.04 DWI pattern Expert 36% 90% 67% 77% 74% Non-expert 37% 79% 48% 75% 67% Effect size (+ 95% CI) and level of significance (p) 0.01(-0.12;0.14) p=0.8 -0.12(-0.22;-0.01) p=0.045 -0.19(-0.30;-0.08) p=0.003 -0.02(-0.06;0.01) p=0.2 -0.08(-0.13;-0.02) p=0.01 Split scar Expert 26% 89% 51% 74% 70% Non-expert 39% 76% 45% 75% 65% Effect size (+ 95% CI) and level of significance (p) 0.14(-0.07;0.34) p=0.2 -0.13(-0.26;0.004) p=0.07 -0.06(-0.22;0.10) p=0.46 0.01(-0.04;0.06) p=0.7 -0.05(-0.12;0.02) p=0.2 Note, results were calculated using a complete response as the positive outcome and residual tumor as the negative outcome. CI = Confidence interval. PPV = positive predictive value. NPV = negative predictive value.

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