Adherence to pulmonary rehabilitation during a 12-month period 91 Obstructive Lung Disease; MRC-score: Medical Research Council dyspnea scale as a measure of disability in patients with chronic obstructive pulmonary disease Fixed effects There was no significant change in adherence (RAdMAT-NL scores) over time, b = 0.01, t(587) = 0.14, p = 0.89 (Figure 1a and Table 2). Table 2 Patient variance of adherence, 6MWD and HRQL in relation to time b SE b 95% CI RAdMAT-NL Time 0.01 0.10 -0.18, 0.20 6MWD Time 0.73 1.35 -1.93, 3.38 HRQL Time -0.03 0.03 -0.09, 0.02 Note: b: beta coefficient; SE: standard error; CI: Confidence Interval; RAdMAT-NL: Rehabilitation Adherence Measure for Athletic Training the Dutch version; 6MWD: six-minute walk distance; HRQL: Health Related Quality of Life Also, the health outcomes exercise capacity (6MWD) and health related quality of life (HRQL) did not significantly change over time (Figure 2a and 3a and Table 2). 6MWD: b = 0.73, t(587) = 0.54, p = 0.59. HRQL: b = -0.03, t(587) = -1.17, p = 0.24. Random effects The relationship between adherence and time showed significant variance in intercepts across patients, SD = 6.83 (95% CI: 6.04, 7.72), c2(1) = 832.32, p < 0.0001 (Figure 1b). In addition, the slopes varied across patients, SD = 0.61 (95% CI: 0.36, 1.05), c2(9) = 53.84, p < 0.0001, and the slopes and intercepts were negatively and significantly correlated, cor = -0.39 (95% CI: -0.62, -0.10). The negative covariance between intercepts and slopes suggested that the associations between time and adherence in the 196 patients depended on different adherence scores in the different patients. The relationship between 6MWD and time and between HRQL and time also showed significant variance in intercepts and slopes across patients (Figure 2b and 3b). 6MWD intercept: SD = 94.29 (95% CI: 84.23, 105.56), c2(1) = 956.71, p < 0.0001; slopes: SD = 13.97 (95% CI 11.55, 16.90), c2(2) = 43.72, p < 0.0001. Slopes and intercepts were negatively and significantly correlated, cor = -0.35 (95% CI: -0.51, -0.17). HRQL intercept: SD = 1.62 (95% CI: 1.43, 1.83), c2(1) = 623.04, p < 0.0001; slopes: SD = 0.26 (95% CI: 0.21, 0.33), c2(2) = 34.50, p < 0.0001, and the slopes and intercepts were negatively and significantly correlated, cor = -0.64 (95% CI: -0.75, -0.49).
RkJQdWJsaXNoZXIy MjY0ODMw