304 Appendices Outcome variables (measurement type) Assessment time Descriptive statistics of raw data Between-group effects TAU+FNC group TAU group Crude effect Adjusted effect 12 months 2.235 (0.530), n = 42 2.080 (0.557), n = 41 0.082 (-0.113 to 0.277) 0.138 (-0.054 to 0.330) 18 months 2.243 (0.512), n = 37 2.110 (0.584), n = 39 0.063 (-0.138 to 0.263) 0.121 (-0.076 to 0.318) Lonelinessa -0.054 (-0.325 to 0.216)d -0.078 (-0.349 to 0.192)d Baseline 3.218 (0.803), n = 51 3.410 (0.769), n = 51 12 months 2.794 (0.774), n = 42 3.031 (0.978), n = 41 -0.141 (-0.454 to 0.173) -0.162 (-0.478 to 0.153) 18 months 2.786 (0.831), n = 37 2.907 (0.862), n = 39 0.041 (-0.284 to 0.366) 0.013 (-0.311 to 0.338) Substance use (self-report) Quantity alcoholb 1.088 (0.691 to 1.712)d 1.078 (0.682 to 1.702)d Baseline 9.588 (14.054), n = 51 6.902 (12.911), n = 51 3 months 8.800 (18.316), n = 35 6.682 (11.597), n = 44 0.947 (0.435 to 2.064) 0.944 (0.428 to 2.083) 6 months 8.909 (13.322), n = 44 4.615 (7.454), n = 39 1.554 (0.834 to 2.896) 1.523 (0.791 to 2.932) 9 months 9.659 (12.903), n = 41 4.615 (6.319), n = 39 1.646 (0.812 to 3.337) 1.597 (0.798 to 3.197) 12 months 7.143 (9.651), n = 42 5.857 (9.527), n = 42 0.750 (0.379 to 1.487) 0.750 (0.371 to 1.517) 18 months 5.684 (10.419), n = 38 4.135 (8.011), n = 37 0.831 (0.362 to 1.903) 0.876 (0.398 to 1.930) Quantity cannabisb 1.088 (0.666 to 1.779)d 1.175 (0.726 to 1.902)d Baseline 0.510 (0.987), n = 51 0.510 (0.834), n = 51 3 months 0.486 (0.702), n = 35 0.477 (1.023), n = 44 1.164 (0.594 to 2.280) 1.311 (0.686 to 2.504) 6 months 0.727 (1.283), n = 44 0.436 (0.821), n = 39 1.668 (0.821 to 3.388) 1.857 (0.935 to 3.692) 9 months 0.366 (0.536), n = 41 0.359 (0.628), n = 39 0.991 (0.475 to 2.069) 1.064 (0.520 to 2.179) 12 months 0.405 (0.828), n = 42 0.524 (0.917), n = 42 0.653 (0.296 to 1.444) 0.697 (0.306 to 1.585) 18 months 0.526 (0.862), n = 38 0.432 (0.765), n = 37 1.073 (0.519 to 2.216) 1.136 (0.566 to 2.279) Quantity hard drugsb 0.794 (0.228 to 2.766)d 0.885 (0.320 to 2.451)d Baseline 0.216 (0.757), n = 51 0.118 (0.475), n = 51 3 months 0.324 (0.912), n = 34 0.273 (1.662), n = 44 0.863 (0.136 to 5.489) 0.999 (0.158 to 6.333) 6 months 0.250 (0.719), n = 44 0.026 (0.160), n = 39 6.211 (1.059 to 36.416)* 6.159 (1.177 to 32.238)* 9 months 0.220 (0.475), n = 41 0.000 (0.000), n = 38 NA NA 12 months 0.238 (0.532), n = 42 0.643 (3.091), n = 42 0.313 (0.064 to 1.538) 0.356 (0.103 to 1.232) 18 months 0.105 (0.311), n = 38 0.162 (0.602), n = 37 0.784 (0.173 to 3.554) 0.725 (0.157 to 3.357) Days alcoholb 1.020 (0.599 to 1.737)d 0.982 (0.600 to 1.608)d Baseline 6.647 (9.492), n = 51 6.137 (9.633), n = 51
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