302 Appendices Table 1. Crude and adjusted treatment effects on primary and secondary outcomes from intention-to-treat analyses (N = 102). Outcome variables (measurement type) Assessment time Descriptive statistics of raw data Between-group effects TAU+FNC group TAU group Crude effect Adjusted effect Primary outcome Mental wellbeing (self-report)a -0.222 (-0.468 to 0.023)d -0.193 (-0.434 to 0.047)d Baseline 3.797 (0.967), n = 50 3.622 (1.146), n = 51 3 months 3.732 (0.921), n = 35 3.825 (1.083), n = 44 -0.176 (-0.524 to 0.171) -0.154 (-0.497 to 0.190) 6 months 3.879 (1.029), n = 44 4.054 (1.211), n = 39 -0.362 (-0.701 to-0.022)* -0.337 (-0.674 to 0.000)* 9 months 3.951 (0.827), n = 41 4.002 (1.092), n = 39 -0.184 (-0.528 to 0.160) -0.162 (-0.502 to 0.177) 12 months 3.993 (0.926), n = 42 4.033 (1.196), n = 42 -0.178 (-0.515 to 0.158) -0.151 (-0.484 to 0.182) 18 months 3.953 (0.918), n = 39 3.948 (1.062), n = 39 -0.271 (-0.619 to 0.076) -0.234 (-0.578 to 0.111) Key secondary outcomes Psychiatric functioning General psychiatric functioning (observer-rated)a 0.026 (-0.097 to 0.149)d -0,009 (-0.139 to 0.120)d Baseline 0.866 (0.434), n = 51 0.891 (0.445), n = 51 3 months 0.933 (0.493), n = 35 0.780 (0.365), n = 44 0.128 (-0.045 to 0.301) 0.091 (-0.086 to 0.269) 6 months 0.790 (0.441), n = 44 0.737 (0.358), n = 39 0.038 (-0.132 to 0.207) 0.003 (-0.172 to 0.177) 9 months 0.833 (0.469), n = 41 0.744 (0.402), n = 39 0.056 (-0.116 to 0.228) 0.024 (-0.152 to 0.200) 12 months 0.772 (0.450), n = 42 0.764 (0.506), n = 42 -0.034 (-0.203 to 0.135) -0.070 (-0.243 to 0.103) 18 months 0.757 (0.457), n = 37 0.785 (0.487), n = 38 -0.032 (-0.207 to 0.144) -0.067 (-0.246 to 0.113) Hospitalization Number in addiction and psychiatric care (self-report)b 0.936 (0.454 to 1.887)d 0.976 (0.488 to 1.952)d 3 months 0.04 (0.208), n = 45 0.10 (0.303), n = 50 0.467 (0.100 to 2.176) 0.450 (0.094 to 2.143) 6 months 0.11 (0.383), n = 45 0.09 (0.291), n = 44 1.255 (0.313 to 5.022) 1.232 (0.308 to 4.931) 9 months 0.12 (0.328), n = 42 0.14 (0.516), n = 43 0.828 (0.215 to 3.189) 0.848 (0.206 to 3.481) 12 months 0.07 (0.261), n = 42 0.12 (0.400), n = 41 0.584 (0.129 to 2.637) 0.593 (0.133 to 2.647) 18 months 0.22 (0.584), n = 37 0.15 (0.362), n = 40 1.544 (0.512 to 4.658) 1.635 (0.558 to 4.790) Number in internal mental healthcare institute (medical record)b 12 months 0.167 (0.476), n = 48 0.192 (0.495), n = 47 0.870 (0.310 to 2.447) 1.020 (0.304 to 3.424)
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