239 Supplementary material | Appendix A A Section and Topic Item # Checklist item Reported on page # Results of syntheses 20a For each synthesis, briefly summarise the characteristics and risk of bias among contributing studies. 36, Table 1 20b Present results of all statistical syntheses conducted. If meta-analysis was done, present for each the summary estimate and its precision (e.g., confidence/credible interval) and measures of statistical heterogeneity. If comparing groups, describe the direction of the effect. Table 3, Table 4, Appendix A: Table 3.1-3.7 20c Present results of all investigations of possible causes of heterogeneity among study results. 56-57, Table 4, Appendix A: Table 3.1-3.7 20d Present results of all sensitivity analyses conducted to assess the robustness of the synthesized results. 56-57, Table 4 Reporting biases 21 Present assessments of risk of bias due to missing results (arising from reporting biases) for each synthesis assessed. 57, Appendix A: Table 5, Figure 3-8, GRADE evidence profile Certainty of evidence 22 Present assessments of certainty (or confidence) in the body of evidence for each outcome assessed. Appendix A: GRADE evidence profile DISCUSSION Discussion 23a Provide a general interpretation of the results in the context of other evidence. 59 23b Discuss any limitations of the evidence included in the review. 60 23c Discuss any limitations of the review processes used. 60 23d Discuss implications of the results for practice, policy, and future research. 61-62 OTHER INFORMATION Registration and protocol 24a Provide registration information for the review, including register name and registration number, or state that the review was not registered. 30 24b Indicate where the review protocol can be accessed, or state that a protocol was not prepared. 30 24c Describe and explain any amendments to information provided at registration or in the protocol. - Support 25 Describe sources of financial or non-financial support for the review, and the role of the funders or sponsors in the review. See published article Competing interests 26 Declare any competing interests of review authors. See published article Availability of data, code and other materials 27 Report which of the following are publicly available and where they can be found: template data collection forms; data extracted from included studies; data used for all analyses; analytic code; any other materials used in the review. See published article Appendix A: Data coding instrument
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