Vascular risk factors for depression and apathy | Part 1 62 Abstract Objective Vascular disease and neuroticism are both risk-factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life. Methods Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into 4 levels: none, ≥2 vascular risk factors, cardiac disease or stroke. Results Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95%-CI: 1.4-1.8). In men vascular disease, interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95%-CI: 0.6-0.9; stroke by neuroticism: OR: 0.8, 95%-CI: 0.6-0.96) when predicting CRDS. Conclusions In men vascular disease attenuates the predictive effect of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.
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